Myocardial ischemia can be identified by metabolic alterations detected with PET imaging, perfusion defect reversibility detected by CMR with adenosine/Lexisan, dipyridamole
or dobutamine, regional wall motion abnormalities seen by echocardiography and CMR, or ECG changes detected by standard stress test treadmill.
M2 EQUITYBITES-August 30, 2017-Zydus Cadila receives FDA approval to market its aspirin and extended release dipyridamole
M2 PHARMA-August 30, 2017-Zydus Cadila receives FDA approval to market its aspirin and extended release dipyridamole
Ali M et al in their study conclude that the patients with left bundle branch block showing moderate to severe reversible perfusion defects on dipyridamole
thallium cardiac SPECT have high likelihood of coronary artery disease16.
Aspirin alone or in combination with dipyridamole
reduces the recurrence of stroke by 18% and 37%, respectively (17).
dopidogrel (Plavix)[R]), aspirin/ dipyridamole
(Aggrenox[R]), and cilostazole (Pletal[R]), prevent platelet aggregation and/or platelet activation, inhibiting adhesion of platelets and clot formation.
The various antiplatelet agents available include Aspirin, P2Y12inhibitors like Ticlopidines, Clopidogril, Prasugrel, Ticagrilor, Dipyridamole
, Cilostazol, GP 11b IIIa inhibitors.
The blood vessel dilator, dipyridamole
, has demonstrated in early studies its effectiveness as a treatment for pterygium and early-stage pinguecula, also known as 'surfer's eye.
On the other hand, dipyridamole
may be used in pharmacologic stress echocardiography but it is less frequently used because the mechanism of action is based on perfusion changes rather than straight effects on myocardial contractility.
Aspirin (50 mg-325 mg daily) monotherapy or the combination of aspirin 25 mg and extended-release dipyridamole
200 mg twice daily is recommended.
It may also interact negatively with certain prescription medications and over-the-counter drugs, including: NSAIDs (such as aspirin and ibuprofen); warfarin (Coumadin); ticlopidine (Ticlid); clopidogrel (Plavix); and dipyridamole
(Persantine) alprazolam (Xanax), haloperidol (Haldol), Trazodone (Desyrel), omeprazole (Prilosec), and nifedipine (Procardia).
In the PRoFESS trial, clopidogrel was found to be roughly equivalent to combination of ASA and dipyridamole