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dornase alfa

   Also found in: Medical, Wikipedia 0.02 sec.
dor·nase al·fa  (dôrns lf, -nz)
n.
A genetically engineered enzyme used to hydrolyze the DNA in bronchial mucus, facilitating its expectoration, in the treatment of cystic fibrosis.
[Alteration of (recombinant human) d(e)o(xy)r(ibo)n(ucle)ase (1) + alteration of alpha.]
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The two most common mucolytics on the market today are dornase alfa (Pulmozyme) and N-acetylcysteine (NAC), commonly referred to as Mucomyst.
Mucus and sputum: what drug therapy works? by Gardenhire, Doug / FOCUS: Journal for Respiratory Care & Sleep Medicine
org/cgi/content/full/36/9/e100 A Crossover, Randomized, Controlled Trial of Dornase Alfa Before Versus After Physiotherapy in Cystic Fibrosis.
In other journals by New Zealand Journal of Physiotherapy
6 years old, the mean lung function at baseline was 92% of the predicted normal value of FEV1, and the use of concomitant medications included inhaled antibiotics (37%), dornase alfa (Pulmozyme([R])) (77%) and oral macrolide antibiotics (40%).
Inspire Announces Achievement of Primary Endpoint in Phase 3 Trial ... by Business Wire
 
 
 
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