downregulation

(redirected from down regulation)
Also found in: Medical.
Related to down regulation: Upregulate

downregulation

(ˌdaʊnrɛɡjʊˈleɪʃən)
n
(Medicine) a decrease in sensitivity, through overexposure, to a drug or other chemical caused by a reduction in the number or density of receptors on cell surfaces
References in periodicals archive ?
Research teams at Medigene will work with scientists at RXi to explore potential advantages of transient down regulation of certain genes to prevent negative regulation of T cells expressing a recombinant TCR directed against a predefined tumor antigen.
It's down regulation play an important role in development and progression of breast cancer and may serve as potential biomarker11.
RNAi-directed down regulation of OsBADH2 results in aroma (2-Acetyl-1-pyrroline) production in rice (Oryza sativa L.
2010) found non-significant down regulation of TNF-a in adipose tissues after treatment with nobiletin: flavonoid found in citrus fruits.
Cytotoxic T lymphocyte Antigen 4 (CTLA-4), similar to co-stimulatory molecule CD28, plays an important role in down regulation of T cell activation.
Em outras palavras, duas pessoas podem ter o mesmo perfil regulatorio, ao fazer mais uso da down regulation do que da up regulation, mas difiram no uso de estrategias funcionais (modificacao da situacao, reorientacao da situacao, reavaliacao positiva da situacao negativa, expressao de emocoes negativas) e disfuncionais (desamparo aprendido, ruminacao, abuso de substancias e reacao impulsiva--acting out).
Trigonelline, a natural alkaloid found in fenugreek, is known to inhibit adipogenesis by its influences on the expression of peroxisome proliferator-activated receptor (PPAR[gamma]), which leads to subsequent down regulation of PPAR-[gamma] mediated pathway during adipogenesis.
The team found that STAT3 down regulation, via enhanced expression of PIAS3 or exposure to a peptide derived from PIAS3, inhibited cell growth and increased apoptosis in cancer cells.
These results were only partially confirmed by the results of the protein plasmas levels which found very significant up-regulation of IL-2 and down regulation of IL-6, borderline p-values for IL-8 and non-significant results for TNF-[alpha].
Treatment of adipocyte with of TG down regulates the peroxisome proliferatoractivated receptor (PPAR-[gamma]) and CCAAT element binding protein (C/EBP-[alpha]) mRNA expression, which leads to further down regulation of other gene such as adiponectin, adipogenin, leptin, resistin and adipocyte fatty acid binding protein (aP2) as compared with respective control cells on 5th and 10th day of differentiation.
Long-term administration of an LHRH analogue will eventually lead to down regulation of LHRH receptors, thus suppressing FSH and LH secretion.
influenzae, to find a down regulation of genes called claudins that encode proteins key to keeping the spaces between epithelial cells tight.