downregulation

(redirected from down regulation)
Also found in: Medical.
Related to down regulation: Upregulate

downregulation

(ˌdaʊnrɛɡjʊˈleɪʃən)
n
(Medicine) a decrease in sensitivity, through overexposure, to a drug or other chemical caused by a reduction in the number or density of receptors on cell surfaces
References in periodicals archive ?
Trigonelline, a natural alkaloid found in fenugreek, is known to inhibit adipogenesis by its influences on the expression of peroxisome proliferator-activated receptor (PPAR[gamma]), which leads to subsequent down regulation of PPAR-[gamma] mediated pathway during adipogenesis.
The team found that STAT3 down regulation, via enhanced expression of PIAS3 or exposure to a peptide derived from PIAS3, inhibited cell growth and increased apoptosis in cancer cells.
These results were only partially confirmed by the results of the protein plasmas levels which found very significant up-regulation of IL-2 and down regulation of IL-6, borderline p-values for IL-8 and non-significant results for TNF-[alpha].
Molecular approached involved in this study include gene expression studies of the phosphate transporter (Pht1) family from foxtail millet (Seterica italica), construction of a homology models of all expressed SiPht1genes, down regulation of the major low P inducible root and shoot transporters by RNAi, cloning the most significant members of this family and confirm their function by expression in heterologous systems.
Treatment of adipocyte with of TG down regulates the peroxisome proliferatoractivated receptor (PPAR-[gamma]) and CCAAT element binding protein (C/EBP-[alpha]) mRNA expression, which leads to further down regulation of other gene such as adiponectin, adipogenin, leptin, resistin and adipocyte fatty acid binding protein (aP2) as compared with respective control cells on 5th and 10th day of differentiation.
Long-term administration of an LHRH analogue will eventually lead to down regulation of LHRH receptors, thus suppressing FSH and LH secretion.
influenzae, to find a down regulation of genes called claudins that encode proteins key to keeping the spaces between epithelial cells tight.
Muscle fatigue with an aberrant spinal cord reflex preventing activation of golgi tendon organs in the muscle also leads to hyper-stimulation without down regulation.
It has also shown in previous studies that dopamine induces down regulation of DAT and cocaine induces up regulation of DAT by changing the surface level expression.
He told the European Society of Human Reproduction and Embryology (ESHRE)annual conference in Berlin: ``The favourable outcome may be explained by a tranquillising effect which leads to stress reduction and down regulation of the autonomic nervous system.
Il-Moo Chang (Korea) - Study on the Potential Anti-cancer Activities of Iridoids through the Down Regulation of Constitutive STAT3 Activation in Human Prostate Carcinoma DU145 Cells
We propose to address the hypothesis that it is possible to develop a radical approach to management of intraocular pressure employing an V-mediated system for increasing the permeability of Schlemms canal endothelial cells (SCEC), based on published supportive data from this laboratory showing that RNAi-mediated down regulation of mRNA encoding components of tight junctions of neuronal vascular endothelia induces increased cell permeability, a process which has been used to validate a procedure for acute treatment of neuronal edema.