downregulation


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Related to downregulation: Upregulation

downregulation

(ˌdaʊnrɛɡjʊˈleɪʃən)
n
(Medicine) a decrease in sensitivity, through overexposure, to a drug or other chemical caused by a reduction in the number or density of receptors on cell surfaces
References in periodicals archive ?
As expected from the mechanism of action of rigosertib, the treated cells exhibited downregulation of the PI3K/AKT pathway and cell cycle checkpoint proteins.
Downregulation of TIP30 has been found to lead to the expression of osteopontin, matrix metalloproteinase-2, and vascular endothelial growth factor, suggesting that downregulation of this protein promotes metastatic progression of lung cancer.
Furthermore, this dual targeting approach allows persistent disease suppression in in vivo animal models, even in the event of BCMA downregulation or loss.
extract ameliorates isoproterenol-induced cardiomyopathy through downregulation of oxidative, inflammatory and apoptotic molecules in rodent model.
Some studies suggest that the Gly16 allele showed enhanced downregulation of [beta]2-AR, whereas the Glu27 allele was relatively resistant to downregulation of [beta]2-AR during exposure to [beta]2-AR agonists26.
Medical devices company EnteroMedics Inc (NASDAQ:ETRM) revealed on Thursday the receipt of the European patent titled "Treatment of excess weight by neural downregulation in combination with compositions" for the durable treatment of obesity.
We found significant downregulation of the KLRC3 gene in patients with diabetes compared to healthy controls.
With aging and certain genetic mutations (such as that seen in Chediak-Higashi syndrome), reduction of catalase and sometimes downregulation of antioxidant proteins such as BCL-2 and TRP-2 are reduced, resulting in higher reactive oxygen species (ROS) that lead to bulbar melanocyte malfunction and death.
The lone exception was a hema-topoietic-specific miRNA, miR-223, which is abundantly expressed in polymorphonuclear lymphocytes (PMNs) and is associated with downregulation of acute inflammation and tissue remodeling.
This elevated SAH compared to SAM is caused by downregulation of the SAHH enzyme (also called the AHCY enzyme) often due to genetic SNP's.