Phase 3 Trial for Treatment of Cervical Dystonia
- Expects to Initiate Trial in Second Quarter of 2018
It now plans to proceed to a phase three programme in cervical dystonia
based on the phase two safety and efficacy results, along with guidance from the US FDA and the EMA.
This was consistent with dystonia
, a movement disorder characterized by sustained or intermittent muscle contractions causing abnormal movements and/or postures--often initiated or worsened by voluntary action.
They have hyper excitability, using some music instrument lead to brain changes which leads to dystonia
His part posteroventral sensorimotor, target of Leksell and Laitinen, was recognized as the optimal target lesion surgery (pallidotomy) in the treatment of Parkinson's disease and dystonia
The physiological effect of lesioning or deep brain stimulation (DBS) on these nuclei is still unknown, but the most likely explanation is that the damping effect of PD is alleviated by high-frequency stimulation of the STN, while the inverse happens in dystonia
, where stimulation of the globus pallidus interna (GPi) dampens the abnormal tone and movements.
is the third most common movement disorder and is characterized by sustained or intermittent muscle contractions causing twisting or repetitive movements and postural abnormalities.
typically begins in one limb, leg or arm and subsequently become generalized.
The report provides a snapshot of the global therapeutic landscape of Dystonia
Se tuvo muy en cuenta para la evaluacion de los resultados dos escalas de analisis clinico: Burke-Fahn-Marsden Dystonia
Rating Scale (BFMDRS) (tabla 1) y Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) (tabla 2).
Spasmodic dysphonia (SD) is a laryngeal dystonia
that occurs when speaking.
Up to now, more than 20 loci (from DYT1 to DYT25) have been identified to be the causative loci of primary dystonia
 after the first identified TOR1A (DYT1) gene linked to early-onset primary dystonia