Adverse reactions to vaccinia vaccination range from mild and self-limited to severe and life-threatening, including inoculation site signs and symptoms, constitutional symptoms, generalized vaccinia, eczema vaccinatum
, and progressive vaccinia (1,3).
resulting from the transmission of vaccinia virus from a smallpox vaccinee: an investigation of potential fomites in the home environment.
Patients with AD also are at increased risk for eczema vaccinatum
, a viral skin infection that results from direct vaccination with the smallpox vaccine or, more likely, from close contact with another individual who has been vaccinated.
The vaccine was well tolerated, with no cases of eczema vaccinatum
, myocarditis, or pericarditis.
Washington, May 25 (ANI): A husband-wife scientific team from the La Jolla Institute for Allergy and Immunology have identified the cellular defect that makes eczema sufferers more prone to eczema vaccinatum
, a severe and potentially fatal reaction to the smallpox vaccine.
An immunoglobulin containing antivaccinia antibody for the treatment and/or modification of serious complications of smallpox vaccination, including eczema vaccinatum
, progressive vaccinia, severe generalized vaccinia, and vaccinia infections in people who have skin conditions, such as burns, impetigo, or varicella zoster.
Data suggest that only this group--and not those with eczema--is at increased risk for eczema vaccinatum
is frequently caused by contact transmission (CDC, 2001).
After vaccination, even the uncomplicated skin disease eczema can produce a severe, sometimes fatal condition called eczema vaccinatum
The upcoming smallpox virus challenge studies are of special interest to the CDC and SIGA due to the successful effort by SIGA at CDC's request to help save the life of a 28-month toddler who had contracted a severe case of eczema vaccinatum
(CID, 2008:46), which had arisen as a complication from smallpox vaccine administration.
is an immune-mediated adverse reaction to vaccinia virus that can occur in persons with ongoing or past history of atopic dermatitis (10).
There were no severe adverse events such as autoinoculation/contact inoculation, eczema vaccinatum
, progressive vaccinia, generalized vaccinia, encephalitis, or the myopericarditis that has been "a major concern" in the U.