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eicosanoid |
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| 22,23,39) Thus, the major inflammatory mediators involved in the inflammatory pain induced by carrageenan are eicosanoids and sympathomimetic amines, whereas the major inflammatory mediators involved in the inflammatory pain induced by formalin are serotonin and histamine, both of which directly activate sensitized nociceptors. 41) Ludwig et al concluded that high concentrations of magnesium inhibit eicosanoid metabolism during the release of arachidonic acid by directly inhibiting the 5-lipoxygenase enzyme. ALA reduces the production of inflammatory substances, and at the same time it enhances the production of less inflammatory eicosanoids and prostaglandins. |
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