Our approach is enabled by the photocatalytic generation of a previously elusive electrophilic
carbyne radical, Which is able to induce c-h bond cleavage.
They catalyse the conjugation of the reduced glutathione (GSH; I3-Glu-Cys-Gly), via its -SH group, to a wide variety of electrophilic
substrates (Zimniak, 2006; Allocati et al.
Molecular electrostatic potential (MEP) mapping explains the nucleophilic and electrophilic
regions in any compound, and proved as very important tool in quantum chemical chemistry.
5,] showing no difference with which have been known that electrophilic
substitution reaction (e.
Accumulating evidence suggests that redox reactive species, including reactive oxygen species (ROS), reactive nitrogen species (RNS) and other electrophilic
molecules, serve as signaling molecules that regulate biological and physiological processes.
Through conjugation with glutathion, it functions in the detoxification of environmental toxins and products of oxidative stress, electrophilic
compounds, including carcinogens and therapeutic drugs.
Samples of nineteen chapters are: general concepts for covalent bonding and constructing Lewis structures for organic molecules; guideline for writing organic molecule isomers and determining number of rings plus pi-bonds; notation in organic chemistry; guide to writing and using condensed formulas and line drawings; summary guidelines for organic nomenclature; summary guide to thermodynamic concepts for organic chemistry; guide to stereochemistry concepts and analysis of reaction stereochemistry as applied to electrophilic
addition; a brief guideline for applying fundamental concepts in NMR spectroscopy.
Oxidative and electrophilic
stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1.
Some drugs are metabolized and converted into active toxic metabolites under the action of CYP450, such as electrophilic
group, free radical, and oxygroup, which can covalently bind macromolecular substances including protein, nucleic acid, and lipid, causing lipid peroxidation and final hepatocyte necrosis.
Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic
lipid oxidation products.
As it is known, carbon tetrachloride that is converted with the cytochrome P-450 in free radicals and electrophilic
intermediates is aggressive hepatotoxin.
In addition to their ability of conjugation of non-polar compounds carrying electrophilic