(redirected from endogenous opioid)
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Any of various compounds that bind to specific receptors in the central nervous system and have analgesic and narcotic effects, including naturally occurring substances such as morphine; synthetic and semisynthetic drugs such as methadone and oxycodone; and certain peptides produced by the body, such as endorphins. Also called opiate.

o′pi·oid′ adj.


a. any of a group of substances that resemble morphine in their physiological or pharmacological effects, esp in their pain-relieving properties
b. (modifier) of or relating to such substances: opioid receptor; opioid analgesic.


(ˈoʊ piˌɔɪd)

1. any opiumlike substance, as the endorphins produced by the body or the synthetic compound methadone.
2. pertaining to such a substance.


adj & n opioide m
References in periodicals archive ?
Central endogenous opioid inhibition of supraoptic oxytocin neurons in pregnant rats.
Professor, University of Michigan, will deliver a plenary on imaging in neuroscience has been chosen to deliver the Jorge Barrio Lecture for Advances in Clinical Research talk: Endogenous Opioid Systems and Resiliency in Humans
Inhibition of hypothalamic gonadotropin-releasing hormone release by endogenous opioid peptides in the female rabbit.
Opioid drugs are agonists that bind to endogenous opioid receptors and mimic the actions of natural morphine-like ligands.
The long-lasting nature of the phenomenon suggests that endogenous opioid analgesia silently continues long after an injury has healed.
These areas partake in the modulation of chronic pain in a fashion similar to the endogenous opioid system (Hohmann & Suplita 2006; Mackie 2010).
Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.
Induction of human cutaneous mast cell degranulation by opiates and endogenous opioid peptides: evidence for opiate and nonopiate receptor participation.
Endorphins are endogenous opioid polypeptide compounds produced during pain and orgasm, and they work as natural pain relievers (8).
Many modulatory effects (both inhibitory and facilitatory) involve the endogenous opioid system.
3) The exact mechanism of action of sugar water is unknown, but is postulated to involve aspects of distraction as well as endogenous opioid release through sweet taste receptors in the mouth.
Electrical currents such as TENS, with low frequency and high amplitude, are also thought to induce endogenous opioid secretion and modulate the ascending pain-control pathway (4).