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endonuclease

   Also found in: Medical, Encyclopedia, Wikipedia 0.01 sec.
en·do·nu·cle·ase  (nd-nkl-s, -z, -ny-)
n.
Any of a group of enzymes that catalyze the hydrolysis of bonds between nucleic acids in the interior of a DNA or RNA molecule.

endonuclease [ˌɛndəʊˈnjuːklɪˌeɪz]
n
(Life Sciences & Allied Applications / Biochemistry) an enzyme that is responsible for scission of a nucleic acid chain, the action of which is not confined to the terminal nucleotide Compare exonuclease
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.endonuclease - a nuclease that cleaves nucleic acids at interior bonds and so produces fragments of various sizes
nuclease - general term for enzymes that catalyze the hydrolysis of nucleic acid by cleaving chains of nucleotides into smaller units
restriction endonuclease, restriction enzyme, restriction nuclease - any of the enzymes that cut nucleic acid at specific restriction sites and produce restriction fragments; obtained from bacteria (where they cripple viral invaders); used in recombinant DNA technology


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Although the intrinsic pathway involves early activation of caspase-9, and the extrinsic pathway is mediated through caspase-8, both lead to activation of the "executioner" caspase-3 and a variety of proteases and endonucleases.
Increased expression of apurinic and apyrimidinic (AP) endonuclease (~ 5-fold) indicates possible activation of DNA repair processes (He et al.
These include restriction endonucleases for cleaving DNA and ligases for joining the fragments, recombinases that can execute a large variety of DNA cleavage and joining reactions.
 
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