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endonuclease |
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endonuclease [ˌɛndəʊˈnjuːklɪˌeɪz] n
(Life Sciences & Allied Applications / Biochemistry) an enzyme that is responsible for scission of a nucleic acid chain, the action of which is not confined to the terminal nucleotide Compare exonuclease ThesaurusLegend: Synonyms Related Words Antonyms
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Although the intrinsic pathway involves early activation of caspase-9, and the extrinsic pathway is mediated through caspase-8, both lead to activation of the "executioner" caspase-3 and a variety of proteases and endonucleases. Increased expression of apurinic and apyrimidinic (AP) endonuclease (~ 5-fold) indicates possible activation of DNA repair processes (He et al. These include restriction endonucleases for cleaving DNA and ligases for joining the fragments, recombinases that can execute a large variety of DNA cleavage and joining reactions. |
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