Once bound to the target, miRNAs behave similar to siRNAs, inducing specific and irreversible endonucleolytic
cleavage event in the target transcripts .
Induction of endonucleolytic
DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.
cleavage of nucleic acids by eubacterial DNA polymerases.
Orderly fragmentation of DNA in the form of a ladder due to endonucleolytic
attack is reportedly considered as a characteristic of apoptosis and DNA fragmentation is considered as one of the later steps in the apoptotic process.
Processing of the intron- encoded U18 small nucleolar RNA in the yeast Saccharomyces cervisiae relies on both exo- and endonucleolytic
2+] ions to block endonucleolytic DNA cleavage ZnS[O.
Micromolar zinc affects endonucleolytic activity in hydrogen peroxide-mediated apoptosis.
During 3' processing, endonucleolytic
cleavage of the 3' ends of the viral DNA results in CA-3'-hydroxyl DNA ends.
activity from Micrococcus luteus that acts on gamma ray induced damage in plasmid DNA of E.
Association of mammalian cell death with a specific endonucleolytic
degradation of DNA.
1) is genetically polymorphic (1), and has been postulated to be a candidate molecule for the endonucleolytic
activity involved in apoptosis or programmed cell death (2) and involved in the initiation of systemic lupus erythematosus (3).
This energy-dependent process involves loss of cell-to-cell contact, cell shrinkage, condensation of nuclear chromatin, and eventual endonucleolytic
fragmentation of genomic DNA.