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Either of two closely related pentapeptides having opiate qualities and occurring in the brain, spinal cord, and other parts of the body.

[Greek enkephalos, in the head (en-, in; see en in Indo-European roots + kephalē, head; see ghebh-el- in Indo-European roots) + -in.]


(ɛnˈkɛfəlɪn) or




(ɛnˈsɛfəlɪn) or


(Biochemistry) a chemical occurring in the brain, having effects similar to those of morphine. See also endorphin


(ɛnˈkɛf ə lɪn)

either of two polypeptides that bind to morphine receptors in the central nervous system and have opioid properties of relatively short duration. Compare endorphin.
[1970–75; < Greek enképhal(os) encephalon + -in1]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.enkephalin - an endorphin having opiate qualities that occurs in the brain and spinal cord and elsewhere
endorphin - a neurochemical occurring naturally in the brain and having analgesic properties
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References in periodicals archive ?
This increase in enkephalin, together with previous work done by this research group which showed that an opioid receptor blocker was less effective at reducing fat and sugar intake in the pups of the junk-food fed mothers, provides evidence for the first time that the opioid signalling pathway is less sensitive in junk-food exposed offspring.
Chemical messengers including serotonin, enkephalins, GABA, and dopamine (DA) work in concert to provide a net release of DA at the nucleus accumbens (NAc), a structure located within the mesolimbic system.
It seems likely that our enkephalin findings in rats mean that this neurotransmitter may drive some forms of overconsumption and addiction in people.
Enkephalin is an endorphin with similar properties to opium.
Activation of the pain control system increases the concentration of beta endorphin, enkephalin, serotonin and norepinephrine levels in the brain tissue and plasma, thus creating an analgesic effect, as well as many others.
Tears include a powerful hormone, leucine enkephalin, which regulates pain and other hormones which regulate stress.
In addition to this newly acquired Endomorphin technology, and our exclusive licenses for GAD, we also have an ongoing clinical development program with Enkephalin," saidsays Elisabeth Lindner, President and CEO of Diamyd Medical.
Higher concentrations of the endogenous opioid enkephalin, as well as gamma-aminobutyric acid, have been measured after HF stimulation; higher concentrations of [beta]-endorphin and serotonin have been found after LF stimulation [28-29].
Peptides such as methionine enkephalin and leucine enkephalin and the proteins chignolin and TRP Cage are examined in this study.
Leucine enkephalin was added through postcolumn infusion to serve as an internal mass calibrant, to confirm analyte identification using accurate mass estimation (Benotti et al.
It stimulates the beta-endorphin and enkephalin synthesis, proving the comfort, well-being and pleasure sensation perceived when applying the product on the skin, favoring skin homeostasis thus inducing an immediate sensorial effect.
Needling affects cerebrospinal fluid levels of endorphin and enkephalin, and such effects can be blocked by the opiate antagonist naloxone.