Celiac disease (CD) is an immune mediated enteropathy
characterized by intolerance to gluten diet and occurs in genetically predisposed individuals1.
AKU researchers under the SEEM grant, Study of Environmental Enteropathy
and Malnutrition in Pakistan funded by the Bill and Melinda Gates Foundation, are studying if malnourished children have a different set of bacteria in their intestines that limit their growth potential and reduce their immunity to disease.
Celiac disease or gluten-sensitive enteropathy
, sometimes also known as sprue or coeliac, "is an immune reaction to eating gluten, a protein found in wheat, barley and rye," according to (https://www.
Experts at Alder Hey Children's Hospital, near the family home in Warrington, Cheshire, diagnosed a life-threatening bowel condition called tufting enteropathy
Background: Celiac disease (CD) (also called gluten-sensitive enteropathy
and nontropical sprue) is a known entity since 1888, is a common immune-mediated enteropathy
due to allergy to gluten, with a prevalence of approximately 1% worldwide.
Celiac disease is a well-recognized auto-immune enteropathy
involving genetic factors, and is associated in almost all patients to specific susceptibility alleles encoding human leucocyte antigen (HLA) histocompatibility antigens, the corresponding genes being localized at the major histocompatibility region in the short arm of chromosome 6.
This disturbance, originally referred to as environmental enteropathy
, is now widely called environmental enteric dysfunction (EED) to reflect its multifaceted manifestations and effects.
DH is strongly linked to celiac disease, a gluten-sensitive enteropathy
(celiac disease): controversies in diagnosis and classification.
There is substantial clinical variability between patients with GoF STAT3 mutations and also overlap in phenotype with other monogenic autoimmune disorders such as immunodysregulation polyendocrinopathy enteropathy
X-linked (IPEX) syndrome (MIM: 304790) resulting from hemizygous loss-of-function forkhead box P3 (FOXP3) mutations, and also early-onset polygenic autoimmune disease.
(EE) and environmental enteric dysfunction (EED) are terms used to describe the same pathophysiological, subclinical condition of reduced small intestinal barrier and absorptive function that has high prevalence among children living in low- to middle-income countries where poor hygiene, inadequate sanitation, and malnutrition pervade (Crane et al.
A hydrogen breath test, upper endoscopy, colonoscopy, abdominal/pelvic CT, and tests for gluten-sensitive enteropathy
and parasites revealed no abnormalities except decreased small intestinal motility, he said.