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A small molecular region of an antigen that binds to a particular antibody or antigen receptor on a T cell; an antigenic determinant. A single antigen can have multiple epitopes.

[epi- + Greek topos, place, spot.]


(Medicine) the site on an antigen at which a specific antibody becomes attached


(ˈɛp ɪˌtoʊp)

a site on an antigen at which an antibody can bind, the molecular arrangement of the site determining the specific combining antibody. Also called antigenic determinant .
[1970–75; epi- + -tope < Greek tópos place; compare topo-]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.epitope - the site on the surface of an antigen molecule to which an antibody attaches itself
immunology - the branch of medical science that studies the body's immune system
site, situation - physical position in relation to the surroundings; "the sites are determined by highly specific sequences of nucleotides"
antigen - any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies)
References in periodicals archive ?
BNP immunoreactivity was analyzed using 2 sandwich immunoassays: one utilizing monoclonal antibody (mAb) KY-BNP-II (epitope 14-21) as capture with mAb 50E1 (epitope 26-32) for detection and a single-epitope sandwich BNP (SES-BNP) immunoassay specific to the epitope 11-17.
One major advantage of anti-peptide antibodies produced against MAPs is that they are targeted against single epitope and presumably could serve as homogenous antibodies similar to monoclonal antibodies.
It is encouraging to see that this kit may have a potential role in future clinical management of CRPC patients, leading to better monitoring and possibly improved survival rates," said Ping Gao, President of Epitope Diagnostics.
The researchers took known IgE binding sites (epitope sequences) from peanut and nut proteins and ran those through the SDAP database in order to predict cross-reactive epitopes in other nuts.
Epitope VSFNQNLEY of NA protein was excellent MHC I promiscuous binder at average binding score 111.
The two HIV-1 gp41 sequences used in this analysis containing neutralizing epitope have been submitted to Genbank under the following accession IDs: EU569806, EU569820.
31, researchers describe a new "epitope-mapping" laboratory test that within three weeks can pinpoint the unique binding site - or epitope - from any antigen where immune system T cells can most securely attach and attack invading germs or errant cells.
Second, the epitopes are MHC class I antigen-restricted, which means that only a fraction of the human population will possess the correct MHC class I molecules capable of presenting a specific epitope and eliciting appropriate and protective CMI responses.
The second edition of this research guide for epitope mapping protocols is designed for immunologists, structural biologists and biotechnologists who need to familiarize themselves with the latest methods for mapping B-cells, T-cells, antibodies and antibody profiling signatures in biological fluids.
JPT offers four delivery options for T-cell assays: 1) Fast Track for proteome-wide T-cell epitope discovery programs 2) Research Track for T-cell epitope mapping studies 3) Discovery Track for immune monitoring applications and 4) Trial Track for vaccination trials.
The rice is specially developed using MAT vector system, a bio technology for genetically extracting the necessary genomes, in this case an epitope into the rice.