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equipotent |
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2] are equipotent activators of CREB phosphorylation in pancreatic islet cells, a response mediated via a "nonclassical" membrane ER (Quesada et al. The chemicals were then combined at equipotent concentrations and the mixture tested using fixed-ratio design. In seminal studies, they demonstrated that neonatal exposure of female mice to equipotent uterotrophic doses of the phytoestrogen genistein (GEN; Figure 1) or the synthetic estrogen diethylstilbestrol (DES) leads to an identical incidence of uterine adenomas at 18 months of age (Newbold et al. |
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