A corollary of the principles of dose addition is that co-exposure to a larger number of chemicals will drive up the extent of such underestimations if these chemicals are present at levels equipotent with the components we used in our experiments.
For example, if a participant received fentanyl, the average hourly amount administered in mcg/hour was multiplied by 60 (potency ratio, ranges from 10 to 100:1 fentanyl to morphine) to obtain the equipotent IV morphine dose administered every 4 hours.
15,16) The current study compares the effectiveness of these two opioid analgesics against severe postoperative pain at equipotent doses in 5 min intervals, the time considered clinically relevant for the reduction of severe pain in postoperative analgesia.
Eventually, such relations tend to be based on sharing and collaboration between commoners, who join their productive capacities together as equipotent peers in networked forms of organization (Bauwens, 2005).
These doses of etomidate, which were assumed to be approximately equipotent to those of propofol, were chosen based on a study in adult rats comparing propofol and etomidate requirements during continuous infusion for achieving comparable levels of burst suppression.