A health care practitioner may also measure levels of estrone and estriol
to obtain a more comprehensive assessment of a woman's estrogen status.
In the first effort of its kind in MS, a team of investigators at seven medical centers has begun a two-year, controlled clinical trial of the hormone estriol
added to standard therapy to treat MS in 130 women with relapsing-remitting MS.
Aside from the first trimester biochemistry and nuchal translucency approach, another option to keep in mind is second-trimester noninvasive screening, which up to now has consisted of testing maternal serum for alpha-feto-protein, human chorionic gonadotropin, and unconjugated estriol
The commonly used triple test, which involves the use of maternal age, serum [alpha]-fetoprotein, unconjugated estriol
, and human chorionic gonadotropin, was expected to have a Down syndrome detection rate of 60-65% and false-positive rate of 5% (1).
Potential research applications for Inhibin-A include, but are not limited to: (a) Menstrual studies; (b) Prenatal screening where assessment of hCG, unconjugated estriol
, AFP and Inhibin-A in association with maternal age and gestational age estimated by ultrasound can detect 75-80% of those with Downs syndrome (5% false positive); (c) Pre-eclampsia as Inhibin is greatly elevated in these pregnancies (d) Polycystic ovarian syndrome (e) Ovarian cancer as a possible marker; (f) Puberty studies as an indicator of maturity, and (g) IVF for monitoring the effects of gonadotropin stimulation.
In addition, the Company is developing a Phase 2 oral estriol
drug, Trimesta, for the treatment of relapsing-remitting multiple sclerosis (MS) and cognitive dysfunction in MS, and a monoclonal antibody combination for the treatment of Pertussis.
A recent study used 8 mg a day of estriol
in women with MS for 6 months to observe the effects of estrogen treatment.
Over the last few months we've seen the startup of a new clinical trial involving the sex hormone estriol
in women with MS and news that two new gene variations are associated with MS susceptibility (see page 74).
The presence of a female fetus was associated with significantly increased maternal circulating monocytes, significantly reduced fetal estriol
and activity of placental 11 beta-hydroxysteroid dehydrogenase type 2, and a trend toward elevated fetal plasma cortisol.
Because of the high concentrations of free estrone and estriol
in pregnancy serum, we had to confirm that no cross-reaction occurred when low concentrations of estradiol esters were determined.
Research found that a surge in the hormone, estriol
, occurs two to three weeks before the onset of spontaneous preterm labor.
In addition, the Company is developing a monoclonal antibody combination for the treatment of Pertussis in collaboration with Intrexon Corporation (NYSE: XON), and a Phase 2 oral estriol
drug for the treatment of relapsing-remitting multiple sclerosis (MS) and cognitive dysfunction in MS.