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Related to estriol: estradiol, estrone


 (ĕs′trī-ôl′, -ōl′, -ŏl′, ĕ-strī′-)
An estrogenic hormone, C18H24O3, that is a metabolite of estradiol and is present chiefly during pregnancy. It is produced by the placenta and is found in the urine of pregnant women.


(ˈɛstrɪˌɒl; ˈiːstrɪ-)
(Biochemistry) the usual US spelling of oestriol


(ˈɛs triˌɔl, -ˌɒl, -traɪ-)

an estrogenic hormone, C18H21(OH)3, occurring in urine during pregnancy.
[1930–35; es(trin) + tri- + -ol1]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.estriol - a naturally occurring estrogenic hormone; a synthetic form is used to treat estrogen deficiency
estrogen, oestrogen - a general term for female steroid sex hormones that are secreted by the ovary and responsible for typical female sexual characteristics


n estriol m
References in periodicals archive ?
A health care practitioner may also measure levels of estrone and estriol to obtain a more comprehensive assessment of a woman's estrogen status.
In the first effort of its kind in MS, a team of investigators at seven medical centers has begun a two-year, controlled clinical trial of the hormone estriol added to standard therapy to treat MS in 130 women with relapsing-remitting MS.
Aside from the first trimester biochemistry and nuchal translucency approach, another option to keep in mind is second-trimester noninvasive screening, which up to now has consisted of testing maternal serum for alpha-feto-protein, human chorionic gonadotropin, and unconjugated estriol.
The commonly used triple test, which involves the use of maternal age, serum [alpha]-fetoprotein, unconjugated estriol, and human chorionic gonadotropin, was expected to have a Down syndrome detection rate of 60-65% and false-positive rate of 5% (1).
Potential research applications for Inhibin-A include, but are not limited to: (a) Menstrual studies; (b) Prenatal screening where assessment of hCG, unconjugated estriol, AFP and Inhibin-A in association with maternal age and gestational age estimated by ultrasound can detect 75-80% of those with Downs syndrome (5% false positive); (c) Pre-eclampsia as Inhibin is greatly elevated in these pregnancies (d) Polycystic ovarian syndrome (e) Ovarian cancer as a possible marker; (f) Puberty studies as an indicator of maturity, and (g) IVF for monitoring the effects of gonadotropin stimulation.
In addition, the Company is developing a Phase 2 oral estriol drug, Trimesta, for the treatment of relapsing-remitting multiple sclerosis (MS) and cognitive dysfunction in MS, and a monoclonal antibody combination for the treatment of Pertussis.
A recent study used 8 mg a day of estriol in women with MS for 6 months to observe the effects of estrogen treatment.
Over the last few months we've seen the startup of a new clinical trial involving the sex hormone estriol in women with MS and news that two new gene variations are associated with MS susceptibility (see page 74).
The presence of a female fetus was associated with significantly increased maternal circulating monocytes, significantly reduced fetal estriol and activity of placental 11 beta-hydroxysteroid dehydrogenase type 2, and a trend toward elevated fetal plasma cortisol.
Because of the high concentrations of free estrone and estriol in pregnancy serum, we had to confirm that no cross-reaction occurred when low concentrations of estradiol esters were determined.
Research found that a surge in the hormone, estriol, occurs two to three weeks before the onset of spontaneous preterm labor.
In addition, the Company is developing a monoclonal antibody combination for the treatment of Pertussis in collaboration with Intrexon Corporation (NYSE: XON), and a Phase 2 oral estriol drug for the treatment of relapsing-remitting multiple sclerosis (MS) and cognitive dysfunction in MS.