ethacrynic acid


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eth·a·cryn·ic acid

 (ĕth′ə-krĭn′ĭk)
n.
A compound, C13H12Cl2O4, used as a diuretic primarily to treat severe edema.

[eth(yl) + acry(lic) + (phe)n(yl) + -ic.]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.ethacrynic acid - diuretic (trade name Edecrin) used to treat edema
diuretic, diuretic drug, water pill - any substance that tends to increase the flow of urine, which causes the body to get rid of excess water
References in periodicals archive ?
The Company announced on November 7, 1994, that based on the results of the Phase II clinical trial of TEKRON(TM), it does not intend to proceed with further development of a topical formulation of ethacrynic acid (ECA) for the treatment of glaucoma.
Ototoxicity caused by the loop diuretics, primarily furosemide and ethacrynic acid, is usually seen in patients with renal failure and in those who receive relatively high doses.
The following drugs may decrease the effectiveness of insulin, resulting in hyperglycemia: acetazolamide, albuterol, asparaginase, calcitonin, corticosteroids, cyclophosphamide, danazol, dextrothyroxine, diazoxide, diltiazem, diuretics, dobutamine, epinephrine, estrogens, ethacrynic acid, HIV antivirals, isoniazid, lithium, morphine, niacin, oral contraceptives, phenothiazines, phenytoin, somatropin, terbutaline, thiazide diuretics, and thyroid supplements.
Based on encouraging preclinical data, the company currently intends to proceed with the development of both an eyedrop formulation of ethacrynic acid and a class of molecules that exhibits pharmacological activity similar to ethacrynic acid as potential new treatments for glaucoma and ocular hypertension.
While we continue to evaluate alternative formulations of the ethacrynic acid ointment, ongoing preclinical testing of analogs of ethacrynic acid were accelerated as a possible alternative to identifying a more acceptable formulation for future development.
Telor is evaluating use of proprietary ethacrynic acid analogs currently in preclinical development and modified formulations of the existing compound for its TEKRON program.
XARANO, a formulation of ethacrynic acid, is to be administered at the time of cataract surgery by the ophthalmic surgeon to prevent or reduce IOP spike by promoting the outflow of fluid from the eye.
Telor has an exclusive worldwide license from the Massachusetts Eye and Ear Infirmary to patents issued in the United States, Canada, Australia, and Europe and pending elsewhere covering the use of ethacrynic acid to lower elevated intraocular pressure.
Food and Drug Administration for its Abbreviated New Drug Application for ethacrynate sodium for injection USP, equivalent to ethacrynic acid 50 mg.
The xenobiotic compounds used for the inhibition bioassays were: bromosulfalein (Dow AgroSciences LLC, Indiana, USA), ethacrynic acid, 97% diethyl maleate, 97% tetraethylthiuram disulfide, and 94% curcumin (all from Sigma, St.
Drugs included in this category are furosemide, bumetanide, ethacrynic acid and tosemide.
For patients who are allergic to sulfa-containing diuretics, doctors sometimes prescribe triamterene, spironolactone, amiloride, or ethacrynic acid.