The xenobiotic compounds used for the inhibition bioassays were: bromosulfalein (Dow AgroSciences LLC, Indiana, USA), ethacrynic acid
, 97% diethyl maleate, 97% tetraethylthiuram disulfide, and 94% curcumin (all from Sigma, St.
Drugs included in this category are furosemide, bumetanide, ethacrynic acid
He was prescribed furosemide for less-than-expected urine output despite having received several doses of ethacrynic acid
For patients who are allergic to sulfa-containing diuretics, doctors sometimes prescribe triamterene, spironolactone, amiloride, or ethacrynic acid
Diuretics that do not contain a sulfonamide group (eg, amilodde hydrochloride, eplerenone, ethacrynic acid
, spironolactone, and triamterene) are safe for patients with an allergy to sulfa.
Exposure of NSC34 cells to Ethacrynic Acid
(EA) or L-Buthionine Sulfoximine (BSO) dramatically reduced the cellular GSH level, and was accompanied by increased production of reactive oxygen species (ROS) measured by the DCF fluorescent oxidation assay.
Inhibition of glutathione-related enzymes and cytotoxicity of ethacrynic acid
Until recently, ethacrynic acid
(Edecrin) was also on market, but now no longer available.
Inhaled tobramycin is not recommended to be given with ethacrynic acid
, furosemide, urea, or mannitol because of the potential for enhanced toxicity.
Simultaneous analysis of flunixin, naproxen, ethacrynic acid
, indomethacin, phenylbutazone, mefenamic acid and thiosalicylic acid in plasma and urine by high-performance liquid chromatography and gas chromatography -mass spectrometry.
The drug in question, ethacrynic acid
, has been approved by the Food and Drug Administration as a diuretic but not for the treatment of glaucoma.