Further, because of the increased risk of inadvertent inoculation, people with other acute, chronic, or exfoliative
skin conditions--such as burns, impetigo, varicella zoster, herpes, severe acne, or psoriasis--are also excluded, as are those with Darier's disease, a hereditary blistering disorder.
Hypersensitivity reactions have included exfoliative
dermatitis, angioneurotic edema and anaphylaxis.
Serious skin reactions such as exfoliative
dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal: Discontinue Dyloject if rash or other signs of local skin reaction occur.
Furthermore, a random selection of 7 isolates were tested by PCR for the exotoxin genes tst, eta, and etb encoding staphylococcal toxic shock syndrome toxin 1, exfoliative
toxin A, and exfoliative
toxin B, respectively (18).
The kit's labeling information states that nonemergency use of the vaccine is not recommended for the following segments of the general population: infants younger than 12 months; pregnant women; people of any age with eczema or other exfoliative
skin conditions; people of any age who are allergic to any element of the vaccine; people of any age on high doses of corticosteroids or immunosuppressive drugs; and people of any age with immunodeficiency related to HIV, leukemia, organ transplant, or other conditions.
An erythematous rash developed that progressed to exfoliative
dermatitis, and the patient was diagnosed with toxic epidermal necrolysis.
NSAIDs can cause serious skin adverse events such as exfoliative
dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal.
People with other acute, chronic, or exfoliative
skin conditions--such as burns, impetigo, varicella zoster, herpes, severe acne, or psoriasis--also are excluded, as are those with Darier's disease, a hereditary blistering disorder.
INFLIXIMAB, A UNIQUE CHIMERIC ANTI-TNF[alpha] MONOCLONAL ANTIBODY FOR THE TREATMENT OF AN EXFOLIATIVE
The following clinically significant, immune-mediated adverse reactions occurred in less than 1% of patients treated with KEYTRUDA: exfoliative
dermatitis, uveitis, arthritis, myositis, pancreatitis, hemolytic anemia, partial seizures arising in a patient with inflammatory foci in brain parenchyma, adrenal insufficiency, myasthenic syndrome, optic neuritis, and rhabdomyolysis.
Sequences specific for sea to see, seg to sei, eta, etb, and tst, which encode staphylococcal enterotoxins (SEA to SEE, and SEG to SEI), exfoliative
toxins (ETA and ETB), and toxic shock syndrome toxin-l, respectively, were detected by using methods described by Jarraud et al.
The case report underscores the need for improved awareness about the extensive use of vaccinia virus for control of rabies in wildlife populations, as well as the dangers of exposure among immuno-compromised individuals and those with exfoliative