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ex·o·nu·cle·ase(ĕk′sō-no͞o′klē-ās′, -āz′, -nyo͞o′-)
Any of a group of enzymes that catalyze the hydrolysis of single nucleotides from the end of a DNA or RNA chain.
(Biochemistry) an enzyme that is capable of detaching the terminal nucleotide from a nucleic acid chain. Compare endonuclease