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The two typical histopathologic features are a) plaques, which are clumps of insoluble [beta]-amyloid protein fragments that accumulate extracellularly, and b) intracellular neurofibrillary tangles composed of altered tau protein (Alzheimer's Association 2003). reported that hetero-VRSA produced three- to five-fold greater quantities of penicillin-binding proteins 2 and 2' and increased quantities of cell-wall precursors, which presumably trap vancomycin extracellularly (39). The present study suggests that the 80% of the particulate material retained in alveolar macrophages or extracellularly in parenchymal lumens may be key to the pathologic sequelae of lung clearance overload that are oriented to the luminal surface in rats. |
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