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extravasate |
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MMPs play an important role in the cleavage of membrane components, enabling leukocytes to extravasate the blood. With an average diameter of approximately 100 nm, sphingosomes readily extravasate through these pores and accumulate within the tumor and slowly release the encapsulated drug. Sphingosomal drugs like Marqibo(R) readily extravasate through the pores of leaky tumor vessels created during angiogenesis and readily accumulate within the tumor. |
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