factor VIII


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Related to factor VIII: Factor VIII deficiency

factor VIII

n.
A protein substance in blood plasma that is an essential part of the blood-clotting process. Most cases of hemophilia are caused by a genetic defect that leads to a deficiency of this factor. Also called antihemophilic factor.

factor VIII

n
(Biochemistry) a protein that participates in the clotting of blood. It is extracted from donated serum and used in the treatment of the commonest type of haemophilia, in which it is absent

factor VIII


n.
an enzyme of blood plasma that is essential to normal blood clotting: lacking or deficient in hemophiliacs.
[1960–65]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.factor VIII - a coagulation factor (trade name Hemofil) whose absence is associated with hemophilia Afactor VIII - a coagulation factor (trade name Hemofil) whose absence is associated with hemophilia A
clotting factor, coagulation factor - any of the factors in the blood whose actions are essential for blood coagulation
References in periodicals archive ?
Si hay que extraer dientes, se deben dar concentrados del factor VIII y mantener un nivel preoperatorio de 80% a 100%.
Campaigners condemned health authority rulings which mean that few patients with haemophilia will be treated with a new super-safe artificial version of the blood product Factor VIII.
The disorder, which leaves its victims vulnerable to life-threatening bleeding episodes, is usually treated with Factor VIII isolated from donated blood plasma.
The major treatments for hemophilia A include recombinant factor VIII drugs such as NovoSeven, Kogenate, Advate, ReFacto, Xyntha, Feiba and others for severe hemophilia cases.
South San Francisco, California-based biotechnology company Genentech, a member of the Roche Group (SIX: RO) (OTCQX: RHHBY) has released positive results from the Phase III HAVEN 3 study evaluating Hemlibra (emicizumab-kxwh) in adults and adolescents (aged 12 years or older) with hemophilia A without inhibitors to factor VIII, the company said.
The study also met a secondary endpoint that once-weekly emicizumab prophylaxis was superior to factor VIII prophylaxis, as demonstrated by a statistically significant and clinically meaningful reduction in treated bleeds in an intra-patient comparison of patients receiving emicizumab prophylaxis compared to their prior factor VIII prophylaxis.
Roche (VTX: ROG) has received approval from the European Commission (EC) for Chugai Pharmaceutical Co Ltd's (TYO: 4519) Hemlibra (emicizumab) for routine prophylaxis of bleeding episodes in people with haemophilia A with factor VIII inhibitors, the Japanese subsidiary disclosed on Wednesday.
NORDIC BUSINESS REPORT-February 28, 2018-Novo Nordisk files for regulatory approval of long-acting factor VIII (N8-GP) in US and EU
s) supply of antihemorrhagic drugs for the treatment of haemophilia, By lots: - lot 1 - dci - coagulation factor viii; - lot 2 - dci - coagulation factor viii and factor von willebrand; - lot 3 - dci - coagulation factor viii and von willebrand factor for von willebrand disease; - lot 4 - recombinant coagulation factor viii; - lot 5 - dci - coagulation factor ix; - lot 6 - dci - nonacog alpha factor ix coagulation; - lot 7 - dci - eptacog alfa activatum; - lot 8 - dci - complex of anti-coagulation inhibitors.
The treatment of hemophilia may involve prophylaxis, management of bleeding episodes, treatment of factor VIII (FVIII) inhibitors, and treatment and rehabilitation of hemophilia synovitis.
Haemophilia is a rare condition where patients present with abnormal bleeding and other complications of bleeding due to genetic or acquired deficiency of coagulation factor VIII (Haemophilia A) or factor IX (Haemophilia B).
Low factor VIII (FVIII) [2] concentrations are associated with hemophilia A, type 2N von Willebrand disease (vWD), and combined factor V/VIII (CFV/VIII) deficiency.