familial hypercholesterolemia


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Noun1.familial hypercholesterolemia - congenital disorder characterized by high levels of cholesterol and early development of atherosclerosis
monogenic disease, monogenic disorder - an inherited disease controlled by a single pair of genes
hypercholesteremia, hypercholesterolemia - the presence of an abnormal amount of cholesterol in the cells and plasma of the blood; associated with the risk of atherosclerosis
References in periodicals archive ?
ORION-9 is a double-blind, randomised multi-national Phase III trial designed to confirm the effectiveness and safety of inclisiran in heterozygous familial hypercholesterolemia patients.
ORION-9 is a double-blind, randomized multi-national Phase III trial designed to confirm the effectiveness and safety of inclisiran in heterozygous familial hypercholesterolemia patients.
The product is a treatment for the rare, life-threatening, genetic cholesterol disorder, Homozygous Familial Hypercholesterolemia (HoFH), and Amryt estimates that there are around 100 patients with HoFH in these countries, with requests for access to Lojuxta made by clinicians throughout the region.
Familial hypercholesterolemia (FH) is a common genetic disorder with an estimated prevalence of heterozygous FH (HeFH) between 1 in 200-500 and homozygous FH (HoFH) between 1 in 160 000-300 000.
2bPrecise selected Mayo Clinic for this work because of their strong subject matter expertise and work in the area of clinical genomics, specifically their research in familial hypercholesterolemia (FH), and for their desire to share their care algorithms more broadly with the medical community.
Type 2 diabetes mellitus, chronic kidney disease stage 3 or 4, or heterozygous familial hypercholesterolemia.
Familial hypercholesterolemia (FH) is a genetic disorder associated with autosomal dominant mutations in any of 3 genes namely LDLR, ApoB, and PCSK9.
At current prices, PCSK9 inhibitors are not cost effective for patients with heterozygous familial hypercholesterolemia or atherosclerotic cardiovascular disease, according to an analysis published Aug.
In May of this year, the agency approved the addition of a new indication for use to the drug's label for the treatment of homozygous familial hypercholesterolemia in patients 7 to 17 years old.
Global Markets Direct's, 'Heterozygous familial hypercholesterolemia (heFH) - Pipeline Review, H1 2016', provides an overview of the Heterozygous familial hypercholesterolemia (heFH) pipeline landscape.
Familial hypercholesterolemia (FH) is a genetically transmitted condition, wherein abnormally high levels of total cholesterol and low density lipoproteins (LDL) are seen.

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