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felid |
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These recent H5N1 influenza viruses have acquired the unprecedented and disturbing capability to infect humans; to cause neurotropic disease and a high proportion of deaths in waterfowl in nature; to cause death in and be transmitted among felid species, including domestic cats (14); and to cause neurotropic disease and death in ferrets and mice (15). The currently circulating H5N1 viruses were reported to infect domestic or wild captive felids, such as tigers, feeding on infected bird carcasses, and the infected cats can transmit H5N1 to pen mates (38). Thus, with the exception of position 627 at PB2 in the leopard isolate, the genomic sequences of these zoo felid isolates did not show substantial differences from other recent H5N1 isolates from Asia. |
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