However, focal expression of S100, c-KIT, glial fibrillary
acidic protein (GFAP), and vimentin can be seen in some tumors (Figure 7, A and B).
Tumor cells are encircled with abundant fibrillary
chondromyxoid ground substance in hemorrhagic background.
Expression of glial fibrillary
acidic protein was weak, and the presence o f Ki-67 protein demonstrated a low proliferation rate (figure 2,C).
The following commercially available antibodies were used: polyclonal antibodies against S100 protein and monoclonal antibodies against epithelial membrane antigen, vimentin, synaptophysin, glial fibrillary
acidic protein (GFAP), CD34, p53, CD3, CD20, AE1/AE3, MIB-1 (all Ventana Medical Systems, Tucson, Arizona), CAM 5.
stem Histo- Post op Cause of Sex resection Involvement pathology Survival Death 4/F Subtotal + fibrillary
11 days B.
2, p63, smooth muscle actin, and glial fibrillary
acid protein yielded negative results.
The cells are fusiform with elongated fibrillary
cytoplasm, and their buckled to spindled nuclei exhibit little atypia.
Microscopic examination revealed spindle cells with fibrillary
cytoplasm arranged in interlacing fascicles & exhibiting nuclear palisading with mild to moderate nuclear pleomorphism.
17) Negative reactivity for S100, h-caldesmon, CD34, and glial fibrillary
acidic protein help in the differential diagnosis with other types of sarcomas (Table).
10) PLGAmay stain with glial fibrillary
acidic protein (GFAP), but this is usually less consistent than is GFAP staining of pleomorphic adenomas.
Immunohistochemical marker [IHC] Glial Fibrillary
Acidic Protein [GFAP] confirmed the diagnosis[Figure 3].
Previously published works limited to small case series and case reports used only neurilemmal markers (eg, Leu-7, glial fibrillary
acid protein, myelinbasic protein, peripherin), S100 protein, and factor XIIIa (a marker of perineurial fibroblasts) to differentiate these 2 entities.