Interpretation & conclusions: The enzyme exhibited similar fibrinolytic
activity as that of streptokinase, on fibrin plates that were devoid of plasminogen, suggesting that its fibrinolytic
action is independent of plasminogen and it is not a plasminogen activator.
c-Phycocyanin (c-pc), a blue coloured, fluorescent protein was purified from blue-green alga, Spirulina fusiformis and its effect on fibrinolytic
system in vascular endothelial cells was investigated.
Patents for this new generation of plasminogen activators and proteases have been filed and the lead protein has shown promising fibrinolytic
activity in in vitro tests.
The use of various fibrinolytic
agents (streptokinase, urokinase, and recombinant tissue-type plasminogen activator [rt-PA]) has been reported in a small number of clinical series with a very limited number of participants, yielding significant variability regarding inclusion criteria, treatment protocol, and outcome analysis.
Activated plasminogen, plasmin, is a fundamental component of the fibrinolytic
system and is the main enzyme involved in the lysis of blood clots and clearance of extravasated fibrin.
0 ml of EBC was obtained in which the following indices were detected: Total protein content (g/L) by Lowry's method, EBC proteolytic activity by the lysis of albumin, azocasein, and azocollagen by Veremeyenko's method, the content of aldehyde and ketone derivatives of 2,4-dinitrophenylhydrazone (AKDNPH) of the main and neutral character by Dubinina's method, the content of nitrogen monoxide metabolites (NMON) by Yemchenko's method (1994) in Gozhenko's modification (2002), total, enzymatic, and non-enzymatic fibrinolytic
activity by Kukharchuk's method.
Natto contains a potent fibrinolytic
and thrombolytic enzyme, nattokinase, and accordingly, it has been postulated that natto may have protective effects of against CVD.
or percutaneous coronary intervention).
First line treatment in ischemic stroke is the administration of tPA, a fibrinolytic
used to potentially dissolve the clot, thereby restoring blood flow to the affected brain tissue.
Objective: To confirm that either Fibrinolytic
therapy or open decortication which of the two is an effective First line treatment of pleural empyema.
Primary fibrinolysis or fibrinogenolysis involves increased fibrinolytic
activity because of the imbalance between plasmin and antiplasmins in favour of the former.
therapy for acute myocardial infarction