Also found in: Medical, Acronyms, Encyclopedia, Wikipedia.


Any of a group of glycoproteins that are found especially in blood plasma and in the extracellular matrix of connective tissue and that play a role in cellular adhesion, embryonic differentiation, phagocytosis, and blood clotting.

[fibro- + Latin nectere, to bind; see ned- in Indo-European roots + -in.]


a glycoprotein which plays a major role in cell growth
References in periodicals archive ?
After the cells adhered overnight, fibronectin (Sigma, USA) was added to the medium at the following concentrations: 0 (control group), 10, 20, 40, 60, and 80 [micro]g/mL.
Fibronectin glomerulopathy is an autosomal dominant genetic disease.
Activated MEKERK signaling by fibronectin in microglia enhances eukaryotic translation initiation factor 4E (eIF4E) phosphorylation through the activation of MAPK-interacting protein kinase-1, which may play a role in regulating P2X4 expression.
Our polymer helps fibronectin act as it does normally within the body.
They discovered that aged muscles contain substantially less fibronectin compared to young muscles.
They used these 3D tissues to test the properties of cells from diabetic foot ulcers and found that cells from diabetic ulcers get stuck making an immature scaffold made up predominantly of a protein called fibronectin that is likely to prevent proper closure of wounds.
The addition of fetal fibronectin added nothing to the predictive value of the cervical measurement, Dr.
Normal fibroblasts form a meshwork of fibronectin that helps support cells.
To evaluate the change in profibrotic and proinflammatory proteins, western blot analyses of TGF-[beta], collagen IV, and fibronectin were performed (Figure 2).
Collection for fFN was with commercial specimen collection kit for fFN, containing 1ml fFN extraction buffer (Fetal Fibronectin Enzyme Immunoassay or Rapid fFN; Hologic Inc.
Fibronectin has been shown to play a major role in many types of cell adhesion [12].
Our approach is guided by the natural diversity found in human fibronectin domains.