Killing adult worms is considered as a superior filarial
control strategy (WHO recommends new drug discovery directed to this strategy) since killing one adult worm will prevent production of thousands of mf that circulate in blood and are responsible for transmission of infection (mosquitoes that transmit infection take-up mf only during their blood meal).
Yong 2013 Molecular phylogeny of filarial
worms (Nematoda: Filarioidea).
The topics include harnessing genomic technologies to explore the molecular biology of liver flukes, identifying and profiling nematicidal compounds in veterinary parasitology, drugs and targets to perturb the symbiosis of Wolbachia and filarial
nematodes, the preclinical development of a human hookworm vaccine, new approaches to antigen discovery and promising new candidates for schistosomiasis vaccines, and vaccines against cestode parasites.
Some species transmit filarial
nematodes, whereas others vector several economically important viral diseases such as Oropouche, blue-tongue, equine encephalitis, epizootic hemorrhagic disease, African horse sickness, Akabane and bovine ephemeral fever (Mellor et al.
Helminth infections include filarial
diseases, onchocerciasis (river blindness) and lymphatic filariasis (elephantiasis) caused by parasitic worms, which inflict the heaviest socioeconomic burden of all the neglected tropical diseases and affect millions in poverty-stricken areas.
for first time reported by Rafae and Alavi in 1963 in Iran.
Tropical pulmonary eosinophilia (TPE) is an interstitial lung disease that results from an exaggerated immune response to filarial
parasites Wuchereria bancrofti and Brugia malayi (1).
Mapping the presence of Wolbachia pipientis on the phylogeny of filarial
nematodes: evidence for symbiont loss during evolution.
9) CTS has also been reported with a filarial
infection alone (10) and in a combined case of loiasis, schistosomiasis, and trypanosomiasis.
Wolbachia may soon become more newsworthy, as they are essential symbionts of the major pathogenic filarial
nematode parasites of humans, including Onchocerca volvulus, which causes river blindness.
Lymphangiosarcoma associated with chronic filarial
Moreover, major filarial
research should have to address the obstacles to eliminate LF and the outcome of post-MDA surveillance of various active LF elimination programmes.