According to Reporternews, Marburg, like other filoviruses
, can be spread by contact with blood, bodily fluids or tissues or contact with contaminated objects.
Yet it remains unclear which species are the definitive reservoirs of filoviruses
The Einstein researchers will explore whether this approach works against disease-causing viruses that are not filoviruses
Tuttle emphasizes his frustration with the unanswered question: why are there so few outbreaks of highly lethal diseases caused by coronaviruses or filoviruses
every year given the abundance and geographic distribution of their presumed bat hosts?
The model now explicitly accounts for nine pathogens, including bacterial and viral diseases, in addition to previously modeled influenza, coronaviruses (such as those responsible for SARS and MERS), and filoviruses
(including Ebola and Marburg).
, EVD and MVD viruses, are known to cause highly fatal HF in humans and non-human primates.
Additionally, the D-peptide target is >95% conserved across all filoviruses
, opening the possibility that this class of inhibitors will also be effective against the closely related Marburg virus.
form filamentous viral particles (see Figure 1).
, including Ebolavirus and Marburgvirus have been linked to bats.
There are no studies in Latin America on Ebola, but if the evolution of the filovirus is as old as American bats (500 million years), one could speculate that some filoviruses
might be present in the Neotropics.
However, bats also are reservoirs for a number of high-consequence zoonoses, including paramyxoviruses, filoviruses
, and lyssaviruses (1).
, in particular, have "gone Hollywood"--portrayed in movies and books because of their spectacular virulence and mysterious origins--they also are cause for fear of their being used as biological weapons, which has spurred a resurgence of research to produce vaccines and improve diagnosis.