We have worked for several years to develop a single vaccine to protect against all the filoviruses
," said John Eldridge, PhD, Chief Scientific Officer of Profectus, who presented the data.
Marburg virus (MARV) and Ebola virus (EBOV) were initially isolated in Africa, but other filoviruses
have been identified on other continents.
, EVD and MVD viruses, are known to cause highly fatal HF in humans and non-human primates.
Additionally, the D-peptide target is >95% conserved across all filoviruses
, opening the possibility that this class of inhibitors will also be effective against the closely related Marburg virus.
TriLink BioTechnologies (TriLink), a leader in manufacturing high quality nucleic acids, today announced that it secured a contract with Battelle for the manufacture of mRNA to support vaccine development against filoviruses
, in particular, have "gone Hollywood"--portrayed in movies and books because of their spectacular virulence and mysterious origins--they also are cause for fear of their being used as biological weapons, which has spurred a resurgence of research to produce vaccines and improve diagnosis.
The snake viruses also have a feature never before seen in any arenavirus--a gene found in the Ebola virus, which is in a completely different class called filoviruses
Lentiviruses are 2 to 4 million years old; filoviruses
, 12 to 30 million years.
Viral haemorrhagic fevers (VHFs) are a group of illnesses caused by several distinct families of viruses: arenaviruses, filoviruses
, bunyaviruses and flaviviruses.
Washington, July 3 (ANI): Modern marsupials, like wallabies and bats, harbour a "fossil" copy of a gene that codes for filoviruses
, which cause Ebola and Marburg hemorrhagic fevers and are the most lethal viruses known to humans, revealed University at Buffalo biologists.
Category A biological agents include: Variola major (smallpox), Bacillus anthracis (anthrax), Yersinia pestis (plague), Clostridium botulinum (botulism), Francisella tularensis (tularemia) and filoviruses
and arena viruses (such as Ebola and Lassa virus which result in viral hemorrhagic fever) (CDC 200511).
They also focus on the activation and evasion of host antiviral signaling pathways by detailing RNA virus families, filoviruses
, suppression of innate immunity, paramyxovirus and orthomyxoviruses, arenaviruses, picornaviruses, togaviruses, coronaviruses and innate immune responses elicited by reovirus and rotavirus.