The statins segment comprises combined market revenue of statin drugs such as atorvastatin, fluvastatin
, rosuvastatin, pravastatin, simvastatin, pitavastatin, and lovastatin.
Contract notice: Supply of Fluvastatin
Tablets or Capsules.
There was no significantly increased risk among people who received fluvastatin
10) en az uc ay sureyle 40-80 mg/gun dozda pravastatin, atorvastatin, fluvastatin
ve simvastatin kullanan 7924 hastayi degerlendirdikleri arastirmada, hastalarin %10,5'inde miyalji gelistigini belirtmislerdir.
One study found that myalgia rates on the highest dose of each respective drug ranged from a low of 5% with extended-release fluvastatin
to 11% with pravastatin, 15% with atorvastatin, and 18% with simvastatin (Cardiovasc.
The synthetic cholesterol lowering statins such as fluvastatin
(III) (Deslypere 1995), cerivastatin (Mc CleIlan and Lynda 1998) were synthesized on the basis of natural product lead, that is, mevastatin (IV) (Yamamoto et al.
First FDA Half-life in Brand name Generic name approval the body Mevacor Lovastatin 1987 Less than 2 hours Zocor Simvastatin * 1991 Less than 2 hours Pravachol Pravastatin 1991 2 hours Lescol Fluvastatin
1993 Less than 3 hours Lipitor Atorvastatin 1996 14 hours Crestor Rosuvastatin 2003 19 hours Lipophilic or Manufacturer and Brand name lipophobic derivation Mevacor Lipophilic Merck, natural compounds Zocor Lipophilic Merck, natural compounds Pravachol Lipophobic Bristol-Myers Squibb, natural compounds Lescol Lipophilic Novartis, synthetic Lipitor Lipophilic Pfizer, synthetic Crestor Lipophobic Pharmaceuticals, synthetic * Low-dose pill approved for over-the-counter sales in U.
4 35 - 45 Rosuvastatin 5 mg Atorvastatin 10 mg Simvastatin 20 mg Lovastatin 40 mg Fluvastatin
80 mg 2.
Statinlerin irdelendigi calismada daha oncesinde yayinlanmis meta-analiz uzerine, karar agaci yontemi ile kurulan model ile 2009 yili maliyet verilerine gore atorvastatin, fluvastatin
, pravastatin, rosuvastatin ve simvastatin ile maliyet-etkililik analizi gerceklestirilmistir.
60] Their in vitro data linked fluvastatin
effects to the induction of cell arrest and apoptosis as well as to an inhibitory effect on angiogenesis and invasion.
Each participant received one of five different statins: fluvastatin
(Lescol[R]), pravastatin (Mevacor[R]), rosuvastatin (Crestor[R]), simvastatin (Zocor[R]), or atorvastatin (Lipitor[R]).
Researchers at Nottingham University said: "Adverse effects were similar across all statin types except liver dysfunction where risks were highest for fluvastatin