TEHRAN (FNA)- Folates
can stimulate stem cell proliferation independently of their role as vitamins, according to a new study that used an in vitro culture and animal model system in their findings.
Provide an Exogenous Signal for C.
1) Once called vitamin B9, it is more commonly referred to as folate
(though there are multiple folates
) or folacin.
are water-soluble B vitamins that offer a number of health benefits, which are supported by European Food Safety Authority (EFSA) approved health claims.
of Animal Science said that they were very surprised to see that there was an almost 30 per cent increase in birth defects in the litters sired by fathers whose levels of folates
were insufficient and severe skeletal abnormalities were also found in the offspirings, that included both cranio-facial and spinal deformities.
Although the human body cannot synthesize folate
or folic acid, during periods of chronic supplementation the body can store folates
, primarily in the liver and in red blood cells (RBCs).
These observations complement recent data published by the same authors, which demonstrate an increase in serum and erythrocyte folates
, and no change in serum cobalamin in NHANES samples during the same time period (5).
of the vitamin B family play an important role in the metabolism of amino and nucleic acids.
More likely explanations include 1) changes over time in the proportion of women taking supplements containing folic acid, 2) decreased consumption of foods rich in natural folates
or foods fortified with folic acid (i.
Naturally occurring folates
, found in leafy vegetables, legumes, and fruits, are believed to be beneficial even at higher intakes.
are tripartite molecules, composed of pterin, p-aminobenzoate (pABA), and glutamate moieties (Fig.
are absorbed by the body at different rates, and not all folate
consumed is absorbed by the body.