demonstrated that by the induction of tumor necrosis factor-[alpha] (TNF-[alpha]), HIF-1[alpha] directly binds with Forkhead
box M1 promoter which is a proliferation-specific transcription factor and subsequently promote HCC cell proliferation with apoptosis resistance.
In our study, 14 of the differentially expressed genes we identified (suppressor of cytokine signaling 2 [SOCS2], lipase E [LIPE], forkhead
box O1 a [FOXO1A], phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [PIK3CG], protein kinase cAMP-dependent type I regulatory subunit alpha [PRKAR1A], protein phosphatase 1 regulatory subunit 3B [PPP1R3B], phosphorylase kinase gamma 1 [PHKG1 ], hexokinase 2 [HK2], protein phosphatase 1 regulatory subunit 3A [PPP1R3A], phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [PIK3CA], phosphoenolpyruvate carboxykinase 2 [PCK2], SHC adaptor protein 3 [SHC3], 3-phosphoinositide dependent protein kinase 1 [PDPK1 ], and AKT serine/threonine kinase 2 [AKT2]), are involved in insulin signaling.
Insulin sensitization of human preadipocytes through glucocorticoid hormone induction of forkhead
35) reported that the antioxidant role of SIRT3 is associated with Forkhead
box class O (FoxO) transcription factors.
This is achieved by the E3-ubiquitin ligases regulating transcription of the Forkhead
Box (FOXO) proteins, including the FOXO3 isoform (Okamoto et al.
FOXO3 is a member of the forkhead
family of transcription factors.
There is substantial clinical variability between patients with GoF STAT3 mutations and also overlap in phenotype with other monogenic autoimmune disorders such as immunodysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome (MIM: 304790) resulting from hemizygous loss-of-function forkhead
box P3 (FOXP3) mutations, and also early-onset polygenic autoimmune disease.
Abbreviations: HFD, high-fat diet; 2-NBDG, 2-(N-(7-nitrobenz-2-oxa-1, 3-diazol- 4-yl) amino)-2-deoxyglucose; AMPK, AMP-activated protein kinase; AKT/PKB, protein kinase B; AS160, Akt substrate of 160 kDa; GLUT1, translocation of glucose transporter 1; IRS-1, insulin receptor substrate; LKB1, liver kinase B1; GSK- 3[beta], glycogen synthase kinase 3[beta]; FoxO1, forkhead
box O1; G6Pase, glucose-6- phosphatase; PEPCK, phosphoenolpyruvate carboxykinase; IR, insulin resistance; HepG2, hepatocellular carcinoma cell line.
Genome-wide gene expression profiling of cancers has consistently identified the Forkhead
Box M1 (FOXM1) as one of the most commonly upregulated genes in the early stages of carcinogenesis (Gartel, 2010).
box class O function: lessons from Drosophila melanogaster.
Vaccination against the forkhead
family transcription factor Foxp3 enhances tumor immunity.
62) Recently, it was reported that the activities of CAFs in lung cancer are regulated by Forkhead
Box F1 (FoxF1), (63) a member of the FOX transcription factor family.