Printer Friendly
Dictionary, Encyclopedia and Thesaurus - The Free Dictionary
3,924,550,427 visitors served.
forum Join the Word of the Day Mailing List For webmasters
?
Dictionary/
thesaurus
Medical
dictionary
Legal
dictionary
Financial
dictionary
Acronyms
 
Idioms
Encyclopedia
Wikipedia
encyclopedia
?

frameshift mutation

   Also found in: Encyclopedia, Wikipedia 0.01 sec.
frame·shift mutation (frmshft)
n.
A mutation in a DNA chain that occurs when the number of nucleotides inserted or deleted is not a multiple of three, so that every codon beyond the point of insertion or deletion is read incorrectly during translation.


Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content.
?Page tools
Printer friendly
Cite / link
Feedback
Add definition
Mentioned in?  References in periodicals archive?   Dictionary browser?   Full browser?
No references found
 
Thus, in contrast to sickle cell disease where there is a single point mutation in all individuals, in the case of, for example, cystic fibrosis, at least 700 are known including mis-sense, nonsense and frameshift mutations, which lead to the production of a faulty protein, faulty processing, faulty regulation of the chloride channel--all of which lead to the symptoms of the disease.
This strain type contains the genes for binary toxin and has an 18-bp deletion and a frameshift mutation in tcdC hypothesized to result in deregulated expression of toxins A and B.
The mutation is caused by a number of genetic errors, including nonsense and frameshift mutations, all of which result in the loss of the ability to synthesize progranulin, said Dr.
 
 
 
Dictionary, Thesaurus, and Translations
?

Terms of Use | Privacy policy | Feedback | Advertise with Us | Copyright © 2012 Farlex, Inc.
Disclaimer
All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.