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frameshift mutation

   Also found in: Encyclopedia, Wikipedia 0.01 sec.
frame·shift mutation (frmshft)
n.
A mutation in a DNA chain that occurs when the number of nucleotides inserted or deleted is not a multiple of three, so that every codon beyond the point of insertion or deletion is read incorrectly during translation.


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where there is a single point mutation in all individuals, in the case of, for example, cystic fibrosis, at least 700 are known including mis-sense, nonsense and frameshift mutations, which lead to the production of a faulty protein, faulty processing, faulty regulation of the chloride channel--all of which lead to the symptoms of the disease.
Genetics and skin disease by Wood, E.J. / Clinical Dermatology
This strain type contains the genes for binary toxin and has an 18-bp deletion and a frameshift mutation in tcdC hypothesized to result in deregulated expression of toxins A and B.
gyrA mutations in fluoroquinolone-resistant Clostridium difficile ... by Fanning, Seamus / Emerging Infectious Diseases
The mutation is caused by a number of genetic errors, including nonsense and frameshift mutations, all of which result in the loss of the ability to synthesize progranulin, said Dr.
Mutation found to cause frontotemporal dementia by Sullivan, Michele G. / Clinical Psychiatry News
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