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frameshift mutation |
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| where there is a single point mutation in all individuals, in the case of, for example, cystic fibrosis, at least 700 are known including mis-sense, nonsense and frameshift mutations, which lead to the production of a faulty protein, faulty processing, faulty regulation of the chloride channel--all of which lead to the symptoms of the disease. The mutation is caused by a number of genetic errors, including nonsense and frameshift mutations, all of which result in the loss of the ability to synthesize progranulin, said Dr. These include frameshift mutations caused by nucleotide insertion or deletion, as well as |
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