So far, the longitudinal personal omics analysis has revealed other important diagnoses that likely would have flown under the radar of conventional Western medicine, including a heart defect in one person that was detected by a simple wearable device, a case of early lymphoma, and a case of MGUS (monoclonal gammopathy
of unknown significance), which is a precancerous condition.
Other conditions associated with pediatric PG include leukemia, IgA monoclonal gammopathy
, Crohn's disease, rheumatoid arthritis, Takayasu disease and various immunodeficiency states including HIV, chronic granulomatous disease, and hyper IgE syndrome.
The most common comorbidity was inflammatory bowel disease (IBD, 35%), followed by hidradenitis suppurativa (14%), rheumatoid arthritis (12%), monoclonal gammopathy
(12%), leukemia (2%), and lymphoma (2%).
The immunodiagnostic tests recommended by the International Myeloma Working Group (IMWG) for the initial symptomatic screening of patients for suspected monoclonal gammopathy
such as multiple myeloma include serum protein electrophoresis (SPEP), serum immunofixation, and serum free light chains (free kappa and free lambda with ratio).
Plasma cell dyscrasias, characterized by the monoclonal growth of plasma cells, include multiple myeloma, Waldenstrom macroglobulinemia (WM), monoclonal gammopathy
of undetermined significance (MGUS), and amyloidosis.
4-fold increased risk of MDS was reported in persons with monoclonal gammopathy
of undetermined significance who had not received anti-myeloma therapy.
The most commonly associated disorders are hematological (myelodysplasia, IgA gammopathy
, and B-cell lymphoma) and inflammatory (ulcerative colitis, Crohn's disease, seropositive arthritis, and sarcoidosis) (3, 4).
It also appears that serum FLCR may still have a role even if MALDI-TOF MS replaces electrophoresis because, in the first report, a significant number of samples that were negative by MALDI-TOF MS did have abnormal serum FLCR, indicating that this new approach is not yet ready to be a single test screen for monoclonal gammopathy
Curcumin's impact on precancerous conditions can be seen in a study of people with "monoclonal gammopathy
of undetermined significance," and "smoldering multiple myeloma.
The patient had a significant medical history of monoclonal gammopathy
of undetermined significance diagnosed in 2008, ovarian cancer, which was treated with surgery and chemotherapy in 2010, and thyroid cancer for which she underwent a thyroidectomy in 2011.
of undetermined significance and other entities associated with monoclonal paraproteins
C3GP: C3 Glomerulopathy; DDD: Dense Deposit Disease; ACP: Alternative Complement Pathway; MPGN: Membranoproliferative Glomerulonephritis; CRP: Complement Regulatory Proteins; MGRS: Monoclonal Gammopathy
Of Renal Significance; Smac: Soluble Membrane Attack Complex