A bullous neutrophilic dermatosis in a patient with severe rheumatoid arthritis and monoclonal IgA gammopathy
The series includes a 10-year epidemiological forecast for diagnosed incident and total prevalent cases of monoclonal gammopathy
of undetermined significance (MGUS) cases, segmented by age and sex.
When he had an evaluation at the hospital clinic, it was determined that he did have indeterminate hyperopacities on MRI of the brain and unspecified monoclonal gammopathy
CD can be seen as a part of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy
and skin changes).
Reagent immunoglobulins used in methods for immunoglobulin quantification are optimized to recognize the diverse constellation of circulating polyclonal immunoglobulins found in physiological states other than monoclonal gammopathy
Although electrodiagnostic features and CSF findings resemble GBS, the very slow progression of symptoms, its chronic relapsing course, the finding of monoclonal gammopathy
of undetermined significance (MGUS) in 40-50% of patients, and a good response to treatment with corticosteroids are making the differential diagnosis easier (24).
Castleman's disease is also associated with Kaposi's sarcoma, non-Hodgkin lymphoma, paraneoplastic pemphigus and POEMS syndrome (peripheral neuropathy, organomegaly, endocrinopathy, monoclonal gammopathy
and skin signs).
In addition, SLE and SS are also associated with some plasma cell dyscrasias, such as monoclonal gammopathy
of undetermined significance, macroglobulinemia, and amyloidosis; however, multiple myeloma (MM) as a lymphoproliferative neoplasm and plasma cell dyscrasia are not nearly as common.
If both cell populations are part of the same clone they could represent marginal zone lymphoma or lymphoplasmacytic lymphoma, (9,10) whereas if they are separate clones, they may indicate a low-grade B-cell lymphoma and a concurrent plasma-cell neoplasm, such as monoclonal gammopathy
of undetermined significance.
Acromegaly associated with monoclonal gammopathy
of undetermined significance (MGUS).
However, there are some case reports and series containing a limited number of cases of hypogammaglobulinemia, monoclonal gammopathy
of undetermined significance (MGUS), and multiple myeloma (3), (4), (5), (6), (7), (8), (9), (10), (11).
Scleromyxedema without monoclonal gammopathy
is a rare and atypical variant of lichen myxedematosus.