gemcitabine


Also found in: Medical, Wikipedia.

gem·cit·a·bine

(jĕm-sī′tə-bēn′)
n.
A nucleoside analog, C9H11F2N3O4, used in its hydrochloride form in the treatment of pancreatic cancer and in combination with other drugs to treat breast, ovarian, and non-small cell lung cancer.

[gem-, perhaps shortening and alteration of CCRF-CEM, designation of the leukemia cell culture on which it was first tested + -citabine, nucleoside analog antiviral and anticancer drug suffix; see zalcitabine.]
References in periodicals archive ?
We review the current evidence for the efficacy and safety of gemcitabine as an alternative to temozolomide in GBM treatment including those cases of GBM that do not respond to standard post-operative temozolomide therapy.
NASDAQ: CELG) has released primary endpoint findings and updated results of secondary endpoints from the phase II international LAPACT trial of Abraxane (paclitaxel protein-bound particles for injectable suspension; albumin-bound) plus gemcitabine in patients with locally advanced pancreatic cancer, the company said.
Celgene announced primary endpoint findings and updated results of secondary endpoints from the phase II international LAPACT trial of Abraxane plus gemcitabine in patients with locally advanced pancreatic cancer.
The institute's decision means that adult patients with metastatic pancreatic ductal adenocarcinoma could have access to Abraxane in combination with gemcitabine as a treatment option via the NHS in instances when other combination chemotherapies are unsuitable and they would otherwise have gemcitabine monotherapy.
We mainly tried to analyze two important and widely used chemotherapy combinations of paclitaxel with carboplatin or gemcitabine with cisplatin in treating NSCLC.
The presentation is entitled, A phase I study of DKN-01 (D), an anti-DKK1 monoclonal antibody, in combination with gemcitabine (G) and cisplatin (C) in patients (pts) for first-line therapy with advanced biliary tract cancer (BTC).
Hypothesis/Purpose: The efficacy can be improved without obvious signs of toxicity by increasing the treatment dose; the efficacy of gemcitabine can be improved by coadministration of a Gloriosa superba extract.
Objective: To evaluate the efficacy of combination chemotherapy; gemcitabine and docetaxel, in terms of objective response, in advanced urothelial carcinoma of urinary bladder.
This study reports the use of intravesical gemcitabine in managing patients with high-risk bladder cancer, refractory to Bacillus Calmette-Guerin (BCG).
Abraxane is intended to be used with gemcitabine, another chemotherapy drug, in patients with pancreatic cancer that has spread to other parts of the body.
The discovery, which allows for a combination of decitabine and gemcitabine to be delivered in pill form, marks a major step forward in patient feasibility for the drugs, which previously had been available solely via injection or intravenous therapy (IV).
The use of IV-administered vitamin C in combination with cytotoxic chemotherapy is further encouraged by a recent report showing that vitamin C potentiated the antitumor activity of gemcitabine against 7 human and 1 murine pancreatic cancer cell lines.