gene amplification


Also found in: Thesaurus, Medical, Legal, Encyclopedia, Wikipedia.

gene amplification

n.
A cellular process characterized by the production of multiple copies of a particular gene or genes to amplify the phenotype that the gene confers on the cell. Drug resistance in cancer cells is linked to amplification of the gene that prevents absorption of the chemotherapeutic agent by the cell.

gene′ amplifica`tion


n.
1. an increase in the frequency of replication of a DNA segment.
2. such an increase induced by a polymerase chain reaction.
[1970–75]
Translations
amplification de gèneamplification génique
Mentioned in ?
References in periodicals archive ?
Hutchison China MediTech , or Chi-Med, has initiated a Phase Ib/II proof-of-concept study of epitinib in glioblastoma patients with epidermal growth factor receptor, or EGFR, gene amplification in China.
c-Myc gene amplification mostly occurs late during tumor formation and is consistently observed in tumor aggressiveness, correlating with poor prognosis and distant metastasis (Singhi et al.
currently the service offers the following assays for diagnostics and predictive testing: her2 gene amplification found in breast/gastric/colorectal cancer gene rearrangement /translocations found in lymphomas alk and ros1 gene rearrangement found in nsclc the fluorescent in-situ hybridisation (fish) technique is performed as a semi-automated assay, on formalin fixed paraffin embedded material.
Oncogenic changes in these receptors may be because of mutations, gene amplification or gene rearrangement leading to constitutive growth factor-independent tyrosine kinase activity.
For VP7 gene amplification, in RT-1 reaction, denaturation of template and primers [Bov9Com3 (Forward) and Bov9Com5 (Reverse)] was done at 970C for 5 min.
0 array (9) and low coverage sequencing (10), and ERBB2 gene amplification has been investigated by real-time quantitative PCR and droplet digital PCR (ddPCR) (11).
Clinical trials of HER2-targeted therapies, including initial studies of trastuzumab (7-11) and lapatinib (12) as well as subsequent trials of pertuzumab (13,14) and trastuzumab emtansine, (15) selected women whose breast cancers had HER2 overexpression, as determined by immunohistochemistry (IHC 3+), or HER2 gene amplification, as determined by FISH (HER2:CEP17 ratio [greater than or equal to] 2.
Gene amplification is the production of many copies of genes located on a restricted region of the chromosome and it is common in cancer cells.
The conclusion was that, the frequent activation of hTERT expression in SCC is not linked with gene amplification (34).
The aim of the Phase 1b open-label trial is to assess the safety and efficacy of 150 mg once-daily (QD) MGCD516, administered orally, in patients with the genetic driver alterations of interest, including RET fusions, DDR mutations, Trk fusions and Trk mutations, CBL mutations and CHR4q12 gene amplification.
At a precise point during oogenesis, the follicle cells surrounding the oocyte exit the cell cycle and enter the gene amplification phase.