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A cellular process characterized by the production of multiple copies of a particular gene or genes to amplify the phenotype that the gene confers on the cell. Drug resistance in cancer cells is linked to amplification of the gene that prevents absorption of the chemotherapeutic agent by the cell.
1. an increase in the frequency of replication of a DNA segment.
2. such an increase induced by a polymerase chain reaction.
amplification de gèneamplification génique