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Related to genotoxic: genotoxic carcinogen


A chemical or other agent that damages cellular DNA, resulting in mutations or cancer.

[New Latin geno-, gene (from Greek genos, race, offspring; see genə- in Indo-European roots) + toxin.]

ge′no·tox′ic adj.
ge′no·tox·ic′i·ty (-sĭs′ĭ-tē) n.


(Genetics) harmful to genetic material


a. genotóxico-a, rel. a una sustancia tóxica nociva al material genético de las células.
References in periodicals archive ?
A study confirmed that its smoke contain toxins like mutagenic, genotoxic and cytotoxic that can lead to cancer, Health news reported.
The atomised smoke Unbar Rothon provided contains scarcely a trace of the carcinogenic or genotoxic substances which can be found in traditionally produced smoked products.
AMRI offers a systematic service to help customers determine and quantify the impact of potential genotoxic impurities (PGI) and elemental impurities on the safety of a drug through toxicological risk assessments to mitigate downstream product risk.
Tenders are invited for "Delivery of laboratory consumables, reagents and materials under the project" Creation of a field detector for the detection of genotoxic activity emitted by military explosives "NATO SPS MYP G5266 in 4 lots: Lot 1:" Consumables for molecular biology "; 2: "Plastics consumables" Lot 3: "Chemicals and reagents" Lot No 4: "Fluocimetric calibration kit".
Bio-Techne said Trevigen products complement its current product portfolio and makes it easier to reach customers interested in products to better understand cell behavior and genotoxic events on cells.
Kummeth, president and CEO of Bio-Techne, the Trevigen products complement Bio-Techne's current product portfolio and make it easier to reach customers interested in products to better understand cell behavior and genotoxic events on cells.
Frequencies of genotoxic (micronucleated and binucleated) and cytotoxic (karryorhetic and karyolitic) cells were scored and compared with the control group.
Many authors evaluated mutagenic and genotoxic effects of glyphosate in its Roundup[R] commercial formulation through micronuclei and comet trials in aquatics organisms (6,8,13,14,16).
Results revealed that the extract was not genotoxic to the erythrocytes of mice even at higher dose of 500 ppm.
2014) and Valavanidis, Vlachogianni, Fiotakis, and Loridas (2013), cytotoxic, genotoxic and mutagenic substances can damage vital cellular mechanisms, such as gene duplication and transcription, changing dramatically the cell division of tissue through cellular aberrations, such as mitotic spindle changes and chromosome breaks, which can trigger and/or potentiate cancerous processes.
Study was carried out to investigate the genotoxic effect of different levels of heavy metals on gill cells of freshwater mussels (Anodonta anatina), a sentinel species in aquatic environment.
As a part of cancer risk assessment, the genotoxic studies are gaining rapid importance.