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Related to genotoxicity: mutagenicity


A chemical or other agent that damages cellular DNA, resulting in mutations or cancer.

[New Latin geno-, gene (from Greek genos, race, offspring; see genə- in Indo-European roots) + toxin.]

ge′no·tox′ic adj.
ge′no·tox·ic′i·ty (-sĭs′ĭ-tē) n.
References in periodicals archive ?
The increase use of pesticides called the attention of several researchers to develop several bioassays in order to evaluate the genotoxicity and mutagenicity effects induced by these agents in microorganisms and mammalian cells [4].
TheMHRA said its tests had found no evidence of genotoxicity - a potential to cause cancer - or chemical toxicity in the filler material.
DDT including p,p'-DDE and DDD cause tumours mainly in the liver of experimental animals and are mostly negative in genotoxicity studies.
In response to this need, a novel in vitro mammalian genotoxicity test has been developed, based on the induction of the human GADD45[alpha] gene in human cells (GreenScreen HC; Gentronix, UK).
Chapters discuss assessment of genetic damage associated with exposure to selenium; prediction of genotoxicities; research problems in the modification of chemical mutagenesis; air pollution, toxicity, and lung cancer; human radiosensitivity; the genotoxicity of herbicides to freshwater microalgae and dental compounds to humans; and other topics.
Mechanisms of genotoxicity of particles and fibers.
The reason behind its non genotoxicity in mammalian test system is the enzyme responsible for conversion of azide into non genotoxic azidoalanine (Arenaz et al.
The Allium cepa assay is an efficient test for chemical screening and in-situ monitoring for genotoxicity of environmental contaminants and has been widely used to study genotoxicity of many pesticides revealing that these compounds can induce chromosomal aberrations in root meristems of A.
The report also highlighted concerns about potential genotoxicity regarding certain nanoparticles of interest to the dying and textile industry.
This manufacturer of silicone-based materials for healthcare, aerospace, electronics and photonics has extended its biocompatibility support to include sensitization, genotoxicity and pyrogenicity testing for its line of pigmented silicone masterbatches.
In January, Pozen said it had submitted findings from a short-term genotoxicity study to the FDA, which showed no chromosomal aberrations were induced in peripheral blood lymphocytes when Treximet was administered for 7 days.
This simple technique is ideally suited for multiplexed parallel processing for applications from genotoxicity analyses to DNA sequencing.