coli producing cyclomodulin and genotoxin
in colon cancer.
Reproductive consequences of paternal genotoxin
exposure in marine invertebrates.
In this context, recent advances in the development of techniques and diagnostic tools have certainly enhanced the understanding of how an organism interacts with its environment at individual, cellular and molecular level, and substantial progress has been made to assess the genotoxin
induced genetic damage in the aquatic biota .
TNT is a haemotoxin, a genotoxin
and carcinogen and I know of women who worked in munitions in World War Two who suffered serious anaemia conditions of the bone marrow as a result.
2) There are several mechanistic classes of genotoxin
and to guard against genotoxic compounds being developed into drugs, it is a regulatory requirement that all pharmaceutical compounds undergo preclinical genotoxic safety testing.
6,7,8,9,10) This method is increasingly being used in molecular epidemiological studies to investigate the impact of nutrition, lifestyle factors, genotoxin
exposure and genotype on DNA damage and cell death.
There are two ways estrogen can induce cancers to form: as a genotoxin
and a mitogen.
The Food and Drug Administration (FDA) characterizes the chemical as a potential human carcinogen and genotoxin
(meaning it can damage DNA), as well as a known neurotoxha.
Labsystems Oy, of Thermo BioAnalysis, signed an exclusive licensing agreement to manufacture and market Vitotox, a high-speed, high- throughput, low-cost toxicity test that tests drugs for genotoxicity, which damages DNA, by using a genetically modified microorganism that emits light when exposed to a genotoxin
triggers FEN1-dependent RhoA activation, cytoskeleton remodeling and cell survival," Journal of Cell Science, vol.
A biosensor for environmental genotoxin
screening based on an SOS lux assay in recombinant Escherichia co/icells.
A second OHSU project will study the effects of a potent genotoxin
present in the seed of the cycad, a tropical palm-like plant.