TNT is a haemotoxin, a genotoxin
and carcinogen and I know of women who worked in munitions in World War Two who suffered serious anaemia conditions of the bone marrow as a result.
2) There are several mechanistic classes of genotoxin
and to guard against genotoxic compounds being developed into drugs, it is a regulatory requirement that all pharmaceutical compounds undergo preclinical genotoxic safety testing.
There are two ways estrogen can induce cancers to form: as a genotoxin
and a mitogen.
The Food and Drug Administration (FDA) characterizes the chemical as a potential human carcinogen and genotoxin
(meaning it can damage DNA), as well as a known neurotoxha.
Labsystems Oy, of Thermo BioAnalysis, signed an exclusive licensing agreement to manufacture and market Vitotox, a high-speed, high- throughput, low-cost toxicity test that tests drugs for genotoxicity, which damages DNA, by using a genetically modified microorganism that emits light when exposed to a genotoxin
The test uses a genetically modified mircroorganism that emits light when exposed to a genotoxin
A biosensor for environmental genotoxin
screening based on an SOS lux assay in recombinant Escherichia co/icells.
A second OHSU project will study the effects of a potent genotoxin
present in the seed of the cycad, a tropical palm-like plant.
Neither of these solvents is considered a genotoxin
or a carcinogen; the weight of evidence from human in vivo studies suggests that exposure to toluene does not cause somatic cell genotoxic damage (7), although this view has been questioned by recent studies of rotogravure printers (8,9).
In addition to bacterial assays, MX is a direct-acting mutagen and genotoxin
in vivo (17-21) and in mammalian cells in vitro (21-27).
GreenScreen HC is a pan-mechanistic detection assay capable of detecting all classes of genetic toxin, as well as being able to detect genotoxins
formed through metabolic activation using S9 mix.
An investigation into the activation and deactivation of chlorinated hydrocarbons to genotoxins
in metabolically competent human cells.