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Related to ghrelin: PYY


A hormone that is secreted by cells in the stomach and promotes hunger before an expected meal, decreases in amount after eating, and promotes secretion of growth hormone.

[Coined by its discoverers from ghrē-, reconstructed Proto-Indo-European root of English grow; see grow + -in (probably influenced by g(rowth)-h(ormone)-rel(easing peptide), a description of ghrelin's function and chemical composition).]


(Biochemistry) a hormone produced in the body that stimulates appetite
[C20: from g(rowth) h(ormone) rel(easing) + -in]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.ghrelin - a gastrointestinal hormone produced by epithelial cells lining the fundus of the stomach; appears to be a stimulant for appetite and feeding, but is also a strong stimulant of growth hormone secretion from the anterior pituitary
gastrointestinal hormone, GI hormones - hormones that affect gastrointestinal functioning
References in periodicals archive ?
Ghrelin is a 28-amino acid peptide produced mainly in the stomach and small intestine.
Results of preclinical trials performed on animals showed low ghrelin levels result in reduced cholesterol and sugar levels, regardless of high-fat diets.
Tests on mice have shown the "homing missile" antibody seeks out and destroys the hormone ghrelin, which increases appetite and inhibits the breakdown of stored fat.
SAN FRANCISCO--Athletic teenage girls who are amenorrheic have higher ghrelin and lower leptin levels than do athletic girls who are eumenorrheic or girls who are nonathletic, according to a small study.
Circulating concentrations of leptin and ghrelin have been measured in healthy and diseased individuals in many studies (1, 2), but there are still limited data about the relative role of maternal and fetal ghrelin and leptin in fetal growth.
RC-1291, designated as a fast-track drug candidate by the FDA for cancer anorexia/cachexia, is an orally active synthetic small molecule ghrelin mimetic.
The vaccine is directed against the naturally occurring hormone ghrelin, which helps regulate energy balance in the body.
A hormone, ghrelin, that triggers hunger might also improve learning and memory.
Scientists now realize that deleting the gene tied to ghrelin also deleted obestatin; the deletion of both the hunger and the fullness signal then had no net effect.
Conversely, the sleep-deprived patients experienced elevated levels of ghrelin, a hormone mostly produced by the stomach that makes you hungry for flies in the first place.
But they moved closer when it was discovered that while the hormone ghrelin boosts appetite in humans, it may have the opposite effect in poultry.