glutaminase


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glutaminase

(ɡluːˈtæmɪˌneɪz; ˈɡluːtəmɪˌneɪz)
n
(Biochemistry) biochem an enzyme used to treat cancer
References in periodicals archive ?
Majority of children with type 1 diabetes produce and deposit anti-tissue trans glutaminase antibodies in the small intestine.
Calithera Biosciences announced that clinical data from its lead product candidate CB-839, a first-in-class glutaminase inhibitor, will be presented at the 2018 Genitourinary Cancer Symposium, February 8-10, 2018 in San Francisco, California.
Combination treatment with the first-in-class glutaminase inhibitor CB-839 and nivolumab is well tolerated and shows clinical activity in patients with three types of cancer, including advanced melanoma, according to initial results of a phase 1/2 study
23] Gln is converted to Glu by the glutaminase in presynaptic neurons.
CB-839 is an investigational orally administered glutaminase inhibitor currently in Phase 1/2 clinical studies.
species characteristics 1 Isolated from: antarctic soil samples [18], soil, Michigan [19], desert sand [20]; amylolythic activity (2) 2 Isolated from: El Mellah lake, Algieria [4], mangrove [21], soil, China [22],Produces: acarviostatins [23], 3 glutaminase [24]; amylolythic activity Strong amylolythic activity 4 Isolated from: a mixture of fresh horse and pig manure [19], mouldy hay, mushroom compost [20].
Ehrlich Ascites Tumor Cells Expressing Anti-Sense Glutaminase RNA Lose Their Capacity to Evade the Mouse immune System.
Theanine incorporated into brain is reported to reduce the release of glutamate from pre-synapse to the synaptic cleft by acting as a Gin transporter and inhibiting the incorporation of extracellular Gin into neurons, which suppresses the conversion of Gin to Glu by glutaminase (Kakuda et al.
Sua degradacao, tambem em glutamato, e realizada pela enzima glutaminase a qual e predominantemente presente em celulas do sistema imune, dos rins e do intestino (Cruzat, Alvarenga e Tirapegui, 2012; Fontana, Valdes e Baldissera, 2003).
Some of these side effects are due to An associated glutaminase activity inherent to some Forms of the enzyme (Andrade, Borges & Silveira, 2014).
Expression and activity of pH-regulatory glutaminase in the human airway epithelium.
Glutaminase has been recognized in bacteria, fungi, yeasts, and mammals.
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