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Related to glycosaminoglycan: chondroitin sulfate, proteoglycan, Hyaluronan


n. Abbr. GAG
Any of a group of unbranched polysaccharides with high molecular weight that contain amino sugars and often are attached to or form complexes with proteins. Also called mucopolysaccharide.

[glycose, hexose (variant of glucose) + amino- + glycan.]


(ˌglaɪ koʊs əˌmi noʊˈglaɪ kæn)

any of a class of polysaccharides that form mucins when complexed with proteins. Formerly, mucopolysaccharide.
[1975–80; glyco- + (hexo)samin(e) a hexose derivative + -o- + glycan polysaccharide]
References in periodicals archive ?
Capillary electrophoresis for the analysis of glycosaminoglycans and glycosaminoglycan-derived oligosaccharides.
Detailed studies indicated the mouse failed to produce sufficient quantities of the enzyme beta-glucuronidase, which normally helps break down metabolic by-products called glycosaminoglycans.
Controlled enzymatic synthesis also enables the placement of other glycosaminoglycan sugars and unnatural sugars at precisely defined positions in the sugar chain creating new novel sugar compounds.
Reddy GK, Chandrakasan G, Dhar SC (1989) Studies on the metabolism of glycosaminoglycans under the influence of new herbal anti-inflammatory agents.
This highly porous, cross-linked matrix of collagen fibers (from cowhide) and a carbohydrate polymer (from shark cartilage) called glycosaminoglycan has since been used successfully to treat more than 100 severely burned patients who had lost most of their skin down to the muscle.
HA is a glycosaminoglycan that frequently accumulates in the area outside the cell, also known as the extracellular matrix, of many solid tumors including prostate, breast, lung, pancreas, stomach and colon.
Halozyme's ENHANZE technology is based on a proprietary recombinant human enzyme rHuPH20 that targets hyaluronan, a glycosaminoglycan, which is a chain of natural sugars found throughout the body and as a component of the extracellular matrix, to aid in the dispersion and absorption of other injected therapeutic drugs.
Hyaluronic acid (HA) or glass acid is a naturally occurring non-sulfated glycosaminoglycan.
Heparin is a glycosaminoglycan polysaccharide with a carbohydrate backbone consisting of alternating uronic acid and hexosamine.
It is also a glycosaminoglycan distributed widely throughout connective, epithelial and neural tissues.
This enzyme degrades HA, a glycosaminoglycan extracellur matrix constituent that can contribute to signs of aging on the skin.
Urinary glycosaminoglycan excretion as a biochemical marker in patients with bladder carcinoma.