Currently, there is no cure for OA, and therapies available rely on reducing symptoms (corticosteroids, NSAIDs, and analgesics) or on the administration of glycosaminoglycans
by different routes.
It is an inherited disease of metabolism that means the body cannot properly break down long chains of sugar molecules called mucopolysaccharides or glycosaminoglycans
3) This extracellular matrix is a combination of the fibrous proteins collagen and elastin, along with water-binding glycosaminoglycans
(PSGAGs) have been used for decades in a variety of species for the management of osteoarthritic pain.
The primary composition of this matrix is a natural ratio of complex proteins including glycosaminoglycans
, collagen, elastin, desmosine, isodesmosine and transforming growth factor.
Cartilage is packed with protein-sugar complexes known as aggrecans, each made of about 100 highly charged molecules called glycosaminoglycans
In MPS I, cells lack the IDUA enzyme, allowing abnormal accumulation of a group of large molecules called glycosaminoglycans
in the brain and other organs.
The new assay aids early diagnosis by detecting carbohydrate structures specific to glycosaminoglycans
in the cells, urine, and blood of MPS patients.
Other examples of glycosaminoglycans
in the human body include chondroitin sulfates, ketatan sulfate, heparin, heparan sulfate, and dermatan sulfate.
Specific topics include human gangliosides and bacterial lipo-oligosaccharides in the development of automminune neuropathies, biotinylated multivalent glycoconjugates for surface coating, N-linked glycoprotein analysis using dual-extraction ultrahigh-performance liquid chromatography and electrospray tandem mass spectrometry, microarray-based study of carbohydrate-protein building, metabolics in glycomics, extraction of chondroitin/dermatan sulfate glycosaminoglycans
from connective tissue for mass spectrometric analysis, and characterization of polysaccharides using mass spectrometry for bacterial serotyping.
Other options for initial adjunct therapy include a 12% ammonium lactate lotion or cream, which supports the epidermis and glycosaminoglycans
in the dermis.
Known as Seatone, this formula contains Biolane TM, ( an extract of the New Zealand Green Lipped Mussel), anti- inflammatory agents, immune modulators and many essential building blocks such as proteins, minerals, glycosaminoglycans
and marine long chain fatty acids.