Results in the first patient dosed with ABO-101 suggest strong CNS and broader systemic distribution, with the potential to reduce levels of glycosaminoglycans
(GAGs) that represent the lysosomal storage pathology central to MPS IIIB disease progression.
(GAGs) are highly negatively charged sugar chains that are covalently bound to a protein core to form aggrecan, which is one of the primary matrix molecules of cartilage.
For healthy cartilage, your dog needs hyaluronic acid, collagen, and glycosaminoglycans
The SimGlycan master database is updated with curated (a) N-glycans derived from Monoclonal antibody (mAb), Bovine Fetuin, Chinese Hamster Ovary (CHO), (b) glycosaminoglycans
derived from Low Molecular Weight Heparin (LMWH), and (c) polysaccharides derived from plants.
Dynamic ECMs form the microenvironment around cells and are composed of collagens, glycoproteins, glycosaminoglycans
(GAGs), and proteoglycans (PGs).
(GAGs) and proteoglycans (PG) in addition to collagen are the main components of extracellular matrix (ECM).
Changes in glycosaminoglycans
and related proteoglycans in intrinsically aged human skin in vivo.
The 17 chapters explore simple and complex carbohydrates and glycoconjugates; methods of structural analysis of glycosaminoglycans
, applications of these methods for identification of lysosomal storage diseases, and participation in the development of Lyme disease; the role of viral envelope protein glycosylation in the pathogenesis of influenza A virus; the application of lectin histochemistry in the diagnosis of lysosomal storage diseases; computational approaches for studying carbohydrate-lectin interactions in infection; the pathogenic effects of altered sialylation of specific glycoconjugates in genetic diseases; sialyltransferase regulation of cancer-associated O-glycans; and the history of pectin study, chemistry, and medicinal uses of pectin.
are comprised of GAGs chains of native proteoglycans and GAGs derived from the degradation of both blood and tissue PGs.
Analogous suggestions have been made, for example, for osteoarthritis, to recommend for patients with low incomes to replace glycosaminoglycan
-containing chondroprotectors with natural glycosaminoglycans
that are abundant, for example, in animal cartilages and chicken wings .
Hurler Syndrome occurs when the body lacks a particular enzyme that breaks down glycosaminoglycans
(GAGs), a type of sugar molecule utilized by our cells to help build bones, cartilages, tendons, corneas of the eyes, skin and other types of connective tissues.
The MPS are a group of lysosomal storage disorders caused by deficiency of enzymes catalyzing the degradation of glycosaminoglycans
and characterized by intralysosomal accumulation and increased excretion in urine of partially degraded glycosaminoglycans
, which ultimately results in cell, tissue and organ dysfunction (2).