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n. (used with a sing. verb)
The study of organisms or environmental conditions that have been rendered free of bacteria or contaminants or into which a known microorganism or contaminant has been introduced for research purposes.

[Greek gnōtos, known; see gnō- in Indo-European roots + biotics, study of living organisms.]

gno′to·bi·ot′ic adj.


(Biology) (functioning as singular) the study of organisms living in germ-free conditions or when inoculated with known microorganisms
[C20: from Greek, from gnōtos, from gignōskein to know + bios known life]
ˌgnotobiˈotic adj
ˌgnotobiˈotically adv


a branch of biology that studies animals under germ-free conditions.
See also: Biology
References in periodicals archive ?
I will adapt and apply these state-of-the-art imaging techniques to a research effort at the Norwegian University of Science and Technology (NTNU) designed to replace trial-and-error management of bacteria in larval cod production with an evidence-based gnotobiotic system that has been developed at NTNU.
The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice.
Pathology of US porcine epidemic diarrhea virus strain PC21A in gnotobiotic pigs.
2-7) In the 1960s, germ-free environments and gnotobiotic chicks and poults became available, and research shifted to investigating the effects of introducing pure cultures of normal bacteria and pathogenic bacteria.
The use of epidemiological studies combined with experiments in humanized gnotobiotic mice will allow researchers to better address species differences and elucidate the interaction between arsenic exposure and the gut microbiome in humans.
In one study (33), gnotobiotic mice had increased quantities of phosphocholine and glycine in the liver and increased quantities of bile acids in the intestine.
2006, Short-chain fatty acids protect gnotobiotic Artemia franciscana from pathogenic Vibrio campbellii.
Today, gnotobiotic animals are used in labs around the world (6/18/11, p.
Experimental study of the pathogenicity of Neoaplectana carpocapsae: Gnotobiotic studies in Galleria mellonella.