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n. (used with a sing. verb)
The study of organisms or environmental conditions that have been rendered free of bacteria or contaminants or into which a known microorganism or contaminant has been introduced for research purposes.

[Greek gnōtos, known; see gnō- in Indo-European roots + biotics, study of living organisms.]

gno′to·bi·ot′ic adj.


(Biology) (functioning as singular) the study of organisms living in germ-free conditions or when inoculated with known microorganisms
[C20: from Greek, from gnōtos, from gignōskein to know + bios known life]
ˌgnotobiˈotic adj
ˌgnotobiˈotically adv


a branch of biology that studies animals under germ-free conditions.
See also: Biology
References in periodicals archive ?
The Oklahoma Medical Research Foundation has opened its new Gnotobiotic Mouse Core Facility.
faecalis, in root canals of gnotobiotic mice was sufficient for the settlement of the bacterium in 83.
Prevention of Helicobacter pylori infection by lactobacilli in a gnotobiotic murine model.
Essential role of urease in pathogenesis of gastritis induced by Helicobacter pylori in gnotobiotic piglets.
Gnotobiotic zebrafish reveal evolutionary conserved responses to the gut microbiota.
Gnotobiotic piglet infection model for evaluating the safe use of antibiotics against Escherichia coli O157:H7 infection.
Inducible transfer of conjugative transposon Tn1545 from Enterococcus faecalis to Listeria monocytogenes in the digestive tracts of gnotobiotic mice.
Humanized gnotobiotic animals or mice with a standardized murine microbiome were not used, but they could serve as better models to reduce the individual variations of gut bacteria.
The effect of diet on the human gut microbiome: A metagenomic analysis in humanized gnotobiotic mice.
Horizontal transfer of tet(M) and erm(B) resistance plasmids from food strains of Lactobacillus plantarum to Enterococcus faecalis JH2-2 in the gastrointestinal tract of gnotobiotic rats.