The '438 patent describes administration of a therapeutically effective amount of a CYP17 inhibitor, such as abiraterone acetate, with a therapeutically effective amount of at least one additional therapeutic agent including, but not limited to, an anti-cancer agent, such as mitoxantrone, paclitaxel, docetaxel, leuprolide, goserelin
, triptorelin, seocalcitol, bicalutamide, or flutamide, or a steroid, such as hydrocortisone, prednisone, or dexamethasone, the ruling states.
The hormone treatments that you may have include goserelin
and tamoxifen before surgery if you have a large tumour, to make surgeiy easier or after surgeiy to reduce the risk of the tumour coming back.
Combined androgen blockade with goserelin
and bicalutamide was started three years ago.
Conventional LHRH agonists currently available on the market include leuprolide acetate, buserelin, goserelin
, and triptorelin, each available in depot formulations requiring monthly, three-monthly, four-monthly, or longer-duration injections.
She was progressing on goserelin
and capecitabine at the time of first blood sample in May 2013, which had amplified ERBB2, TP53 mutation (VAF = 6.
No metastases were detected, and treatment with both the nonsteroidal antiandrogen bicalutamide (Casodex) and goserelin
(Zoladex) reduced his PSA level to 0.
The main exclusion criteria were as follows: (1) Pregnancy, (2) current or past history of malignancy, or current contraindication to either goserelin
, Kuntai or Tibolone as documented in the summary of product characteristics for each product, (3) hormone therapy in the last 4 weeks before study entry, or usage of any drug, nutritional supplement, food or Traditional Chinese Medicine against climacteric complaints, (4) psychoactive drugs, (5) body mass index > 28 kg/m [sup]2 , (6) irregular gynecological bleeding in the last 4 weeks before medication start, cervical smear examination with any intraepithelial pathologic change (i.
CHICAGO -- Use of the gonadotropin-releasing hormone agonist goserelin
during chemotherapy for early hormone receptor-negative breast cancer was associated with lower rates of ovarian failure and more pregnancies in the phase III POEMS trial.
The drug, goserelin
, suppresses the ovaries from premature ovarian failure during cancer treatment and seen preserve future fertility.
They all had standard chemo, and half also had monthly shots of goserelin
, a drug to lower estrogen and temporarily put the ovaries at rest.
They examined a wide spectrum of testosterone levels, and the adverse effects of different levels, by temporarily suppressing the normal endogenous gonadal steroids of healthy men aged 20-50 years using subcutaneous goserelin
ADT usually entails the use of injectable drugs known as LHRH agonists, including goserelin
(Zoladex) and leuprolide (Lupron).