granulocyte-macrophage colony-stimulating factor


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Related to granulocyte-macrophage colony-stimulating factor: GM-CSF

granulocyte-macrophage colony-stimulating factor

n. Abbr. GM-CSF
1. A cytokine secreted by a variety of cell types that stimulates progenitor cells in the bone marrow to produce granulocytes (especially neutrophils) and macrophages.
2. A recombinant form of this cytokine, such as the drug sargramostim.
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ProscaVax is OncBioMunes novel immunotherapeutic cancer vaccine consisting of a combination of prostate cancer associated prostate specific antigen (PSA) with the biological adjuvants interleukin-2 (IL-2) and granulocyte-macrophage colony-stimulating factor (GM-CSF).
Colchicine down-regulates lipopolysaccharide-induced granulocyte-macrophage colony-stimulating factor production in murine macrophages J.
The company's pipeline comprises Molgradex, a Phase 3 stage inhaled granulocyte-macrophage colony-stimulating factor (or GM-CSF) for pulmonary arterial proteinosis (or PAP), AeroVanc, an inhaled vancomycin for MRSA infection in Cystic Fibrosis in preparation for Phase 3, and Aironite, an inhaled sodium nitrite in Phase 2 development.
Essential roles for granulocyte-macrophage colony-stimulating factor (GM-CSF) and G-CSF in the sustained hematopoietic response of Listeria monocytogenes-infected mice.
Granulocyte-macrophage colony-stimulating factor enhances the efficacy of hepatitis B virus vaccine in previously unvaccinated haemodialysis patients.
The development, maintenance, differentiation, and function of MPS are regulated mostly by colony-stimulating factor 1 (CSF-1) in homeostatic conditions [34] and by granulocyte-macrophage colony-stimulating factor (GM-CSF) during inflammation [35].
T-VEC uses a genetically modified variant of the herpes simplex type 1 virus (HSV-1) to replicate within tumors, producing the immunostimulatory protein granulocyte-macrophage colony-stimulating factor (GM-CSF), which is known to "promote an anti-tumor immune response," according to Amgen, which is marketing T-VEC as Imlygic.
During the phase three study, which was the basis for the Committee for Medicinal Products for Human Use opinion, Imlygic was claimed to significantly extend the primary endpoint of durable response rates compared with granulocyte-macrophage colony-stimulating factor.
sup][3] Although various treatments have been investigated, including granulocyte-macrophage colony-stimulating factor (GM-CSF), rituximab, plasmapheresis, stem cell transplantation, pulmonary transplantation of macrophage progenitors, marrow transplantation, and lung transplantation surgery, the current gold standard therapy for PAP is whole lung lavage (WLL).
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is part of the family of hematopoietic cytokines.

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