There are several compounds grouped in classes that interact directly with components of the ERS (salubrinal, BiP inducer X (BIX), salicylamide analogs, flavonoids, guanabenz
, and STF083010), chemical chaperons (4-phenylbutyric acid (PBA), tauroursodeoxycholic acid (TUDCA), and trimethylamine oxide (TMAO)), chemicals that inhibit protein degradation (Eeyarestatin, MG132, and Bortezomib), compounds with antioxidant activity (Edaravone, dibenzoylmethane derivatives, and N-acetyl cysteine (NAC)), and drugs controlling calcium signaling (dantrolene and carbazole derivatives) .
In 2009, the sheikh himself was suspended for six months after samples taken from Tahhan, a horse he rode in endurance contests in Bahrain and Dubai, showed traces of the beta blocker guanabenz
and the steroid stanozolol.
The sheikh's trainer, abdullah Bin hizaim, admitted administering Guanabenz
, a drug used to treat high blood pressure in people, and the steroid 16b hydroxy-Stanozol to Tahhan before desert races in Bahrain and dubai, and was given a 12-month suspension.
Some commonly prescribed drugs in this class include alpha methyldopa (Aldomet), clonidine hydrochloride (Catapres), guanabenz
acetate (Wytensin) and guanfacine hydrochloride (Tenex).
Without affecting the related PPP1R15B-phosphatase complex and constitutive protein synthesis, guanabenz
prolongs eIF2 alpha phosphorylation in stressed cells, thereby adjusting the protein production rates to levels manageable by available chaperones.
JOHN'S WORT Paroxetine Nausea, Lethargy, Incoherence Class IA and III Decreases effectiveness antiarrhythmic agents (precipitating arrhythmias) Cyclosporine Decreases cyclosporine concentration due to increased clearance (transplant rejection) Theophylline Decreases serum concentration YOHIMBINE Clonidine, Guanabenz
Decreases blood pressure reduction effect of centrally active agents CNS stimulants (e.