guanosine monophosphate

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guanosine mon·o·phos·phate

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5), who reported that its role is achieved by activating platelet soluble guanylate cyclase and upregulation of adenosine monophosphate and cyclic guanosine monophosphate.
IW-1701 has been shown in non-clinical studies to modulate the nitric oxide/soluble guanylate cyclase/cyclic guanosine monophosphate (NO/sGC/cGMP) signaling pathway, which is believed to be implicated in achalasia and sickle cell disease, and is being investigated for its potential to treat multiple aspects of sickle cell disease pathophysiology, including red blood cell sickling, decreased blood flow, and vascular inflammation.
Phosphodiesterases--a class of enzymes that break down the phosphodiester bond in second-messenger molecules, such as cyclic AMP and cyclic guanosine monophosphate (cGMP).
Glycerine trinitrate infusion 1ug/kg/min-2ug/kg/min was started to achieve pulmonary vasodilation by increasing cyclic Guanosine Monophosphate in the constricted pulmonary vasculature.
NEP inhibitors have been developed that show enhanced diuretic and natriuretic actions through NPs and the second messenger cyclic guanosine monophosphate (cGMP), particularly in the setting of experimental heart failure (HF), in which endogenous ANP and BNP are increased.
The mechanism of PDE5 inhibitors action involves the nitro oxide (NO)/cyclic guanosine monophosphate (cGMP) pathway.
It is a vital constituent of bone and cell membranes and of molecules such as adenosine triphosphate (ATP), nicotinamide adenine dinucleotide (NAD), cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP); it is essential for energy storage and metabolism and it is important for cell signalling and enzyme activation.
Activation of GC-C results in an increase in concentrations of cyclic guanosine monophosphate, both extracellularly and intracellularly.
While on the one hand, nitric oxide acts as the key intracellular messenger in the actions of estrogen and progesterone via the Nitric oxide-cyclic Guanosine Monophosphate (NO-cGMP) physiological pathway, on the other, it is involved in the antioxidant property of the endothelial cells.
Four classes of drugs are available for non-reactive patients, including the prostacyclin agonists, endothelin receptor blockers, PDE5 inhibitors, and most recently agents that increase availability of cyclic guanosine monophosphate.
Sildenafil induces accumulation of cyclic guanosine monophosphate (cGMP) peripherally, in the human corpus cavernosum (Snyder & Bredt, 1991; Uthayathas et al.