guanosine monophosphate

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Related to guanosine monophosphate: adenosine monophosphate, cyclic guanosine monophosphate, Inosine monophosphate

guanosine mon·o·phos·phate

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Activation of GC-C results in an increase in concentrations of cyclic guanosine monophosphate (cGMP), both extracellularly and intracellularly.
PDE5 is responsible for the degradation of cGMP to guanosine monophosphate.
Combined with sexual stimulation, PDE-5 inhibition increases cyclic guanosine monophosphate concentrations, which relaxes the corpus cavernosum smooth muscle, resulting in increased blood flow and intra-cavernosal pressure and facilitating penile erection.
To verify further the involvement of nitric oxide/cyclic guanosine monophosphate signaling pathway, the i-NAME (an inhibitor of NO synthase) 100 [micro]M or MB (a soluble guanylyl cyclase inhibitor) 10.
The effects on secretion and transit are mediated through cyclic guanosine monophosphate (cGMP), which is also believed to modulate the activity of local nerves to reduce pain.
The mechanism seems to involve l-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway (Kulkarni 2007).
B-type natriuretic peptide (BNP) [3] is a circulating hormone that possesses pluripotent actions on cardiorenal and neurohumoral function following activation of its receptor, guanylyl cyclase receptor-A (GC-A), and generation of the second messenger, cyclic guanosine monophosphate (cGMP) (1).
Viagra blocks an enzyme that normally breaks down cyclic guanosine monophosphate (cGMP), the substance that is produced in response to nitric oxide stimulation and is actually responsible for blood vessel dilation.
Nitric oxide binds to the haem moiety of guanylate cyclase and increases its activity by 400-fold, catalyzing the conversion of guanosine triphosphate to cyclic guanosine monophosphate (cGMP).
The inability to digest microorganisms is related to low levels of intracellular cyclic guanosine monophosphate and diminished release of [beta]-glucuronidase.
Sildenafil works by affecting the cyclic guanosine monophosphate (cGMP) and vascular smooth muscle.