Here, we developed an in vitro model to explore the modulation of PTGS2 expression by haplotypes
combining SNPs from both the PR and the 3'-UTR.
The study demonstrated that linked-read sequencing was able to resolve the haplotypes
of parental genomes and to identify single nucleotide polymorphisms (SNPs) within and surrounding disease genes of interest.
Due to its strict maternal inheritance, individuals within a maternal family line should share the same mtDNA haplotypes
, thereby allowing an evaluation of maternal line assignment accuracy (Wan, Wu, Fujihara, & Fang, 2004).
Although a comprehensive understanding of Red Fox ancestry, allowing for admixture, will ultimately require a more extensive sample and nuclear genetic analyses, 2 clear predictions associated with mtDNA would strongly support the hypothesis that Red Foxes were largely native: (1) haplotypes
are all or mostly native; and (2) multiple native haplotypes
occur in the population.
Overall, the 254 VP1 sequences comprised 207 different haplotypes
Meanwhile, the impact of HLA haplotypes
on aGVHD has been rarely studied.
Recent studies in remote sites like the Persian Gulf, islands in South East Asia and Japan, have revealed the presence of endemic haplotypes
in hawksbill nesting and feeding colonies (Nishizawa et al.
The research -- mostly carried out by a group of researchers from the Cyprus Institute of Neurology and Genetics (CING) -- also indicated that Greek Cypriots in particular appear to share some haplotypes
, or DNA signatures, with Calabrian Italians and Albanians, while Lebanese patrilineages also appear to be very close to those of both communities.
Despite this, cloning and sequencing of a portion of the open reading frames of the nad2, nad4, and col mitochondrial loci in the blue crab Callinectes sapidus (Rathbun, 1896) revealed abnormally high levels of heteroplasmy at all loci with as many as 24 haplotypes
in a single individual and the dominant haplotype
accounting for as little as 43.
Six different haplotypes
were identified (Table 3).
To assess the fetal inheritance of maternally transmitted mutations, approaches have been developed to compare the relative amounts of the mutant and wild type alleles or haplotypes
in maternal plasma.
and genotypes were determined within and among the studied sheep breeds using BioEdit software.